767289-06-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 186255-65-2 6-tertiarybutyl-4-hydroxycoumarin 
• 611227-43-1 5-tert-butyl-2-(methoxymethoxy)benzaldehyde 
• 104-15-4 toluene-4-sulfonic acid 
• 2725-53-3 2-hydroxy-5-t-butylbenzaldehyde 

Downstream Products

• 767289-10-1 4-[N-methyl-N-(2'-bromo-5'-methoxybenzyl)]amino-6-tertiarybutylbenzopyran-7-one 
• 767289-09-8 4-[N-methyl,N-(2-bromobenzyl)]amino-6-tertiarybutylbenzopyran-7-one 

Relevant academic research and scientific papers

Metal-free annulative hydrosulfonation of propiolate esters: synthesis of 4-sulfonates of coumarins and butenolides

An efficient metal-free and cost-effective method for the synthesis of coumarin and butenolide 4-sulfonates (46 examples) has been developed. The reaction involves addition of sulfonic acids to ethyl propiolates followed by lactonization, resulting in direct formation of coumarin and butenolide 4-sulfonates. This methodology has been elaborated to Sonogashira and Suzuki coupling including the synthesis of rac-tolterodine.

Regioselective synthesis of chromeno[4,3-c] isoquinolin-11-ones by radical cyclization

A number of 4-tosyloxycoumarins were treated with N-methyl,N-(2- bromobenzyl)amine, and N-methyl,N-(2-bromo-5-methoxybenzyl)amine in refluxing ethanol to give different 4-[N-(2′-bromobenzyl),N-methyl] amino coumarins in 70-75% yield. These tertiary amine