767303-58-2

Basic information

• Product Name: 2-Propyn-1-one, 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)-
• CAS NO: 767303-58-2
• Molecular Formula: C17H14O3
• Molecular Weight: 266.296
• Mol File: 767303-58-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-one, 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-one, 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)-(767303-58-2)
• EPA Substance Registry System: 2-Propyn-1-one, 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)-(767303-58-2)

Safety Data

• Hazardous Substances Data: 767303-58-2(Hazardous Substances Data)

Upstream product

• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 135-02-4 ortho-anisaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 89-95-2 2-methyl-benzyl alcohol 
• 767303-68-4 3-(4-methoxy-phenyl)-1-(2-methoxy-phenyl)-prop-2-yn-1-ol 

Downstream Products

• 71993-33-4 3-chloro-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 150107-86-1 3-iodo-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one 
• 1332698-03-9 2-(4-methoxyphenyl)-3-(phenylselenyl)-4H-chromen-4-one 

Relevant articles and documents

One-Pot Domino Friedel-Crafts Acylation/Annulation between Alkynes and 2-Methoxybenzoyl Chlorides: Synthesis of 2,3-Disubstituted Chromen-4-one Derivatives

A highly regioselective synthesis of 2,3-disubstituted chromen-4-one derivatives is accomplished from readily available internal alkynes and 2-methoxybenzoyl chlorides. The reaction proceeds via a domino intermolecular Friedel-Crafts acylation/intramolecular vinyl carbocation trapping (or oxa-Michael addition)/demethylation reaction sequence. This Lewis acid promoted method features relatively mild reaction conditions to synthesize a variety of 2,3-disubstituted chromen-4-one derivatives in one pot with up to 93% yield. The chromen-2-one (coumarin) product was obtained when 2,6-dimethoxybenzoyl chloride was used as a starting material via an electrophilic aromatic substitution/rearrangement process.

Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source

A diverse set of novel heterocyclic iodoniums was synthesized for the first time. The reactions of these unique iodoniums with environmentally benign water as the oxygen source provided structurally complex oxygen-incorporated heteropolycycles that are essential motifs in natural products and biologically active compounds. The transformation only required low-cost copper acetate. Further derivatization of the obtained polycycles expanded the structural diversity, which is important in the building of chemical libraries for drug discovery.

Copper-free Sonogashira coupling of acid chlorides with terminal alkynes in the presence of a reusable palladium catalyst: An improved synthesis of 3-iodochromenones (= 3-iodo-4H-1-benzopyran-4-ones)

Pd/C is used as an efficient catalyst for the copper-free Sonogashira coupling of acid chlorides and terminal alkynes to afford ynones in high yields (Tables 1 and 3). Cyclization of (2-methoxyaryl)-substituted ynones induced by I2/ammonium cer