71993-33-4

Upstream product

• 4143-74-2 4'-methoxyflavone 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 4143-72-0 1-(2-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 767303-68-4 3-(4-methoxy-phenyl)-1-(2-methoxy-phenyl)-prop-2-yn-1-ol 
• 768-60-5 4-methoxyphenylacetylen 
• 135-02-4 ortho-anisaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 767303-58-2 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one 
• 60-29-7 diethyl ether 
• 7782-50-5 chlorine 
• 3327-24-0 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 101422-63-3 3-bromo-3-chloro-2-(4-methoxy-phenyl)-chroman-4-one 
• 64-17-5 ethanol 
• 623-11-0 1-methyl-4-nitrosobenzene 

Downstream Products

• 101081-17-8 2-(3-bromo-4-methoxy-phenyl)-3-chloro-chromen-4-one 
• 155373-80-1 3-cyano-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one 
• 10173-84-9 2-(4-methoxybenzoyl)-3(2H)-benzofuranone 
• 876505-29-2 2-(4-methoxybenzoyl)benzofuran-3-ol 
• 4143-74-2 4'-methoxyflavone 

Relevant academic research and scientific papers

One-pot synthesis of 3-haloflavones from flavones using Oxone and potassium halide as a halogenation reagent

A two-step, one-pot method has been developed for the synthesis of 3-haloflavones from the corresponding flavones. The method uses Oxone and potassium halide to produce the active molecular halogen in situ. The solvent (methanol) then participates in the reaction to afford the 2-methoxy-3-haloflavanone derivative. After adding sodium hydroxide, the corresponding 3-haloflavone product is obtained in good to excellent yields. This method provides a convenient synthesis of 3-chloro, 3-bromo and 3-iodo flavones from the same flavone starting material.

COMPOUNDS FOR IMMUNOPOTENTIATION

Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.

Synthesis of 3-halogenated flavonoids via electrophile-promoted cyclization of 2-(3-aryl-2-propynoyl)anisoles

Treatment of 2-(1-aryl-3-propynoyl) anisoles 1 with N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) gave the 3-halogenated flavones and their related molecules in moderate yields.

Selective halogenation of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones using phase transfer catalysis and synthesis of 3-chloro- and 3-bromo-flavones

Selective chlorination and bromination of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones have been achieved by their reaction with ammonium chloride/ammonium bromide and hydrogen peroxide in biphase medium using phase transfer catalysis.

A facile preparation of 3-haloflavones using hypervalent iodine* chemistry

Various 3-haloflavones were prepared by the reaction of the corresponding flavone derivatives with iodobenzene diacetate and trimethylsilyl halide under mild reaction conditions. The iodobenzene diacetate could be replaced by the polymer-supported iodoben

The α-Chlorination of Aryl Ketones with Manganese(III) Acetate in the presence of Chloride Ion

The reaction of 2-(4-methoxyphenyl)-4-chromanone with Mn(OAc)3 in the presence of LiCl gave 3,3-dichloro-2-(4-methoxyphenyl)-4-chromanone.The reactions of 2-phenyl-4-chromanone, 1-phenyl-1-propanone, 1,2-diphenylethanone, and 1-tetralone similarly yielded α,α-dichloro derivatives in good yields. 2,2,2-Trichloroacetophenones were obtained from 2,2-dichloroacetophenones, but in the absence of LiCl, 2,2-dichloroacetophenones gave 2,2,3,3-tetrachloro-1,4-butanediones.KCl, NaCl, NH4Cl,AlCl3, and CaCl2 were also employed as the Cl- ion source.Synthetic applicability and the reaction mechanisms are discussed briefly.