767310-75-8Relevant articles and documents
Synthesis and morphine enhancement activity of N-[5-(2-phenoxyphenyl)-1,3, 4-oxadiazole-2-yl]-N′-phenylurea derivatives
Rad, Ali Almasi,Sheikhha, Majid,Hosseini, Rohollah,Tabatabai, Sayyed Abbas,Shafiee, Abbas
, p. 193 - 200 (2007/10/03)
The synthesis of N-[5-(2-phenoxyphenyl)-1,3,4-oxadiazole-2-yl]-N′- phenylurea derivatives is reported. The structures of these compounds are supported by their IR, 1H-NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L-365,260, a known 3-ureido-1,4-benzodiazepine CCK-B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a, 8c, 8h-8j, 8l, 8o have significant effects.