767310-74-7Relevant academic research and scientific papers
Synthesis and morphine enhancement activity of N-[5-(2-phenoxyphenyl)-1,3, 4-oxadiazole-2-yl]-N′-phenylurea derivatives
Rad, Ali Almasi,Sheikhha, Majid,Hosseini, Rohollah,Tabatabai, Sayyed Abbas,Shafiee, Abbas
, p. 193 - 200 (2004)
The synthesis of N-[5-(2-phenoxyphenyl)-1,3,4-oxadiazole-2-yl]-N′- phenylurea derivatives is reported. The structures of these compounds are supported by their IR, 1H-NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L-365,260, a known 3-ureido-1,4-benzodiazepine CCK-B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a, 8c, 8h-8j, 8l, 8o have significant effects.
Design, synthesis, and preliminary pharmacological evaluation of novel thiazolidinone derivatives as potential benzodiazepine agonists
Almasirad, Ali,Ghadimi, Maryam,Mirahmadi, Saeideh,Ahmadian Kodakan, Pouya,Jahani, Reza,Nazari, Maryam,Rezaee, Elham,Azizian, Homa,Rabizadeh, Parmida,Tabatabai, Sayyed Abbas,Faizi, Mehrdad
, (2021/02/01)
Abstract: Thiazolidinones are well-known heterocycles that demonstrate promising biological effects such as anticonvulsant activity. Hybridization of these chemicals with scaffold, which has necessary pharmacophores for binding to the benzodiazepine recep
