76734-38-8Relevant academic research and scientific papers
Method for tubular continuous synthesis of (3-acetoxy-3-cyanopropyl)-methyl phosphinic acid alkyl ester
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Paragraph 0049-0050, (2021/06/23)
The invention provides a method for tubular continuous synthesis of (3-acetoxy-3-cyanopropyl)-methyl phosphinic acid alkyl ester, which comprises the following steps: a) continuously feeding acetic acid-1-cyano-2-propenyl ester, methyl phosphinic acid alkyl ester and an initiator into a mixer, and mixing to obtain a mixed material; b) feeding the mixed material obtained in the step a) from the bottom of a vertical pipeline reactor, and reacting to obtain a reaction mixture; and c) feeding the reaction mixture obtained in the step b) into an evaporator, and purifying to obtain the (3-acetoxy-3-cyanopropyl)-methyl phosphinic acid alkyl ester. The method comprises the following steps: fully mixing reaction raw materials through a mixer, directly introducing the mixture into a vertical pipeline reactor, discharging the material from the upper part of the reactor, introducing the material into an evaporator, and carrying out low-temperature removal and distillation purification to obtain the (3-acetoxy-3-cyanopropyl)-methyl phosphinic acid alkyl ester, the method is simple in process steps, industrial control and continuous production are easy to realize, and the synthesized product is high in purity and good in yield.
Process for the preparation of phosphorus-containing cyanohydrin derivatives
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, (2008/06/13)
The invention relates to a new process for the preparation of compounds of the formula (I) STR1 in which R1 denotes alkyl and R2 denotes H, acetyl or propionyl, by addition of compounds of the formula II STR2 onto compounds of the formula III, using radical-formers, the radical-formers being used being compounds of the general formula IV STR3 in which R3 denotes alkyl or phenyl and R4 denotes alkyl, the reaction being carried out at temperatures in the range from 50° to 100° C., and, for the preparation of compounds of the formula I where R2 is H, then splitting off the radical R2'. Using this process, the compounds of the formula I are obtained in high yield and particular purity.
Phosphorus-containing cyanohydrine derivatives
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, (2008/06/13)
Cyanohydrine derivatives of the formula STR1 wherein R1 and R2 are alkyl, haloalkyl, cycloalkyl, aralkyl or aryl, R3 and R4 are hydrogen, alkyl, phenyl or benzyl, R5 is hydrogen, acyl, trialkylsilyl o
