15667-63-7

Basic information

• Product Name: ACETIC ACID 1-CYANO-2-PROPENYL ESTER
• Synonyms: Acrolein cyanohydrin acetate;2-Acetoxy-3-butenenitrile;Acetic acid 1-cyanoallyl ester;Einecs 239-743-2;Acetic Acid 1-Cyano-2-propenyl Ester DL-2-Acetoxy-3-butenenitrile 1-Cyanoallyl Acetate;ACETIC ACID 1-CYANO-2-PROPENYL ESTER;1-CYANO-2-PROPENYL ACETATE;1-CYANOALLYL ACETATE
• CAS NO: 15667-63-7
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• EINECS: 239-743-2
• Mol File: 15667-63-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 74 °C / 16mmHg
• Flash Point: 72 °C
• Appearance: /
• Density: 1.03
• Vapor Pressure: 0.883mmHg at 25°C
• Refractive Index: 1.4230-1.4250
• Storage Temp.: 2-8°C
• Water Solubility: 15.8g/L at 20℃
• CAS DataBase Reference: ACETIC ACID 1-CYANO-2-PROPENYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ACETIC ACID 1-CYANO-2-PROPENYL ESTER(15667-63-7)
• EPA Substance Registry System: ACETIC ACID 1-CYANO-2-PROPENYL ESTER(15667-63-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24
• Safety Statements: 36/37/39-45
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 15667-63-7(Hazardous Substances Data)

Usage

General Description

ACETIC ACID 1-CYANO-2-PROPENYL ESTER, also known as cyanoacetic acid allyl ester, is a chemical compound with the molecular formula C6H7NO2. It is a colorless to pale yellow liquid with a pungent odor and is commonly used as an intermediate in the manufacture of pharmaceuticals, herbicides, and insecticides. It is also used as a solvent and as a chemical intermediate in organic synthesis. ACETIC ACID 1-CYANO-2-PROPENYL ESTER is considered to be a hazardous chemical and should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system if not properly managed.

InChI:InChI=1/C6H7NO2/c1-3-6(4-7)9-5(2)8/h3,6H,1H2,2H3

Upstream product

• 108-24-7 acetic anhydride 
• 109-75-1 but-3-enenitrile 
• 143-33-9 sodium cyanide 
• 107-02-8 acrolein 
• 773837-37-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 
• 5809-59-6 3-cyano-3-hydroxy-1-propene 

Downstream Products

• 76734-38-8 (3-Acetoxy-3-cyano-propyl)-methyl-phosphinic acid isobutyl ester 
• 13269-47-1 4-amino-3-hydroxybut-1-ene 
• 172529-93-0 3-[n-butoxy(methyl)phosphoryl]-1-cyanopropyl acetate 
• 5809-59-6 3-cyano-3-hydroxy-1-propene 
• 138128-01-5 2-acetyloxy-4-(methylthio)butanoic acid 

Relevant articles and documents

Preparation method and device of 1-cyano-2-propenyl acetate

The invention provides a preparation method of 1-cyano-2-allyl acetate. The preparation method comprises an esterification reaction and distillation. Acrolein cyanohydrin and liquid acetic anhydride are subjected to the esterification reaction in the presence of a catalyst and inorganic acid to prepare a reaction solution containing ACA, an ACA product is obtained after distillation, and the esterification reaction further comprises the step of introducing gaseous acetic anhydride into a reaction system. The invention further provides a preparation device of 1-cyano-2-allyl acetate. Accordingto the method and the device, acetic anhydride is ingeniously divided into two parts to be fed, one part is separated out to serve as acetic anhydride steam which is fed into an esterification reaction tower from the bottom of the tower, heat required by reaction can be provided, acetic acid can be effectively blown off, the esterification reaction can be accelerated through effective removal of acetic acid, and the reaction efficiency is improved. The device is characterized in that a conductivity meter is arranged in the esterification reaction tower to monitor the reaction process on line,so that the timeliness and effectiveness of reaction process control are guaranteed.

PROTEASOME INHIBITING ?-LACTAM PRODRUGS USEFUL FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS

The present invention relates generally to proteasome inhibiting β-lactam compounds useful for the treatment of cancer and neurodegenerative disorders. The invention also provides pharmaceutical compositions and extended release formulations of said compounds, and medical uses of said compounds and/or pharmaceutical compositions to treat cancer and neurodegenerative disorders.

Process for the preparation of 2-hydroxy-4-(methylthio) butanoic acid or methionine by mercaptan addition

A process for the free-radical addition of a mercaptan to a nonconjugated olefinic substrate having a terminal carbon-carbon double bond is disclosed. 2-Hydroxy-4-(ethylthio)butanoic acid (HMBA) or methionine can be prepared using this method. The nonconjugated olefinic substrate has the general formula: STR1 wherein R is selected from the group consisting of --COOH, --COOR2, --CONR3 R4, --CN and --CCl3, R1 is selected from the group consisting of --OH, --OCOR2, --NHCOR2 and --NH2, R2 is selected from the group consisting of alkyl, cycloalkyl and aryl and R3 and R4 are independently selected from the group consisting of --H and R2.