76739-65-6Relevant academic research and scientific papers
Tandem Transannular Radical Cyclizations. Total Synthesis of (+/-)-Modhephene and (+/-)-Epi-Modhephene
Curran, Dennis P.,Shen, Wang
, p. 755 - 770 (1993)
Modhephene and epi-modhephene have been synthesized by a new tandem transannular radical cyclization strategy.The key tandem cyclization is conducted by the Barton thiohydroxamate method with an exo(methylene)cyclooctane.
α-Carbonyl Radicals for Total Synthesis of Natural Products
Sha, Chin-Kang,Jean, Tsong-Shin,Yau, Nei-Tung,Huang, Shih-Jung,Chiou, Ruey-Torn,et al.
, p. 637 - 640 (2007/10/02)
Intramolecular cyclization of α-carbonyl radicals to the trimethylsilylacetylenic side chain gives bicyclic vinylsilane ketones and enones.Application of the cyclization to total synthesis of (+/-)-modhephene is described.
