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2H-Purin-2-one,6-amino-1,9-dihydro-9-(phenylmethyl)-, also known as 6-Aminopurine, is an organic compound with the chemical formula C12H11N5. It is a derivative of purine, a heterocyclic aromatic organic compound consisting of a pyrimidine ring fused to an imidazole ring. 6-Aminopurine is a synthetic purine analog that is widely used in molecular biology and genetics as a mutagen and a radiomimetic agent. It is structurally similar to adenine, one of the four nucleobases found in DNA and RNA, and can be incorporated into nucleic acids during replication, leading to base pair mismatches and mutations. This property makes it a valuable tool for studying DNA repair mechanisms, mutagenesis, and gene expression. Additionally, 6-aminopurine has been used as a fluorescent probe to study the structure and dynamics of nucleic acids, as well as in the development of antiviral and anticancer drugs.

7674-33-1

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7674-33-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7674-33-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,7 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7674-33:
(6*7)+(5*6)+(4*7)+(3*4)+(2*3)+(1*3)=121
121 % 10 = 1
So 7674-33-1 is a valid CAS Registry Number.

7674-33-1Relevant academic research and scientific papers

Synthesis of acyclic nucleotide analogues derived from N3-substituted isoguanine

Alexander, Petr,Holy, Antonin,Budesinsky, Milos,Masojidkova, Milena

, p. 1713 - 1725 (2007/10/03)

Reaction of 9-benzyl-6-{[(dimethylamino)methylidene]amino}purin-2(3H)-one (7) with ethylene carbonate gave a mixture of 9-benzyl-2-(2-hydroxyethoxy)purin-6-amine (10) and 2-amino-9-benzyl-3-(2-hydroxyethyl)purin-2(3H)-one (11). This mixture reacted with diisopropyl (tosyloxymethyl)phosphonate in the presence of NaH followed by catalytic hydrogenation and bromotrimethylsilane treatment to afford isomeric 6-amino-3-[2-(phosphonomethoxy)ethyl]purin-2(3H)-one (3) and 2-[2-(phosphonomethoxy)ethoxy]purin-6-amine (15). Similar treatment of compound 7 with tritylglycidol gave two isomeric 2-hydroxy-3-(trityloxy)propyl derivatives 18, 20 which were subsequently condensed with diisopropyl (tosyloxymethyl)phosphonate to afford protected diester intermediates 21 and 22; these compounds were transformed by hydrogenolysis and ester cleavage with bromotrimethylsilane to the isomeric 6-amino-3-[3-hydroxy-2-(phosphonomethoxy)propyl]-purin-2(3H)-one (2) and 2-[3-hydroxy-2-(phosphonomethoxy)propoxy]purin-6-amine (24). None of the free phosphonates 2, 3, 15 or 24 exhibited any antiviral or cytostatic activity.

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