7674-36-4

Basic information

• Product Name: 9-benzyl-9H-purine-2,6-diamine
• CAS NO: 7674-36-4
• Molecular Formula: C₁₂H₁₂N₆
• Molecular Weight: 240.2639
• Mol File: 7674-36-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 596.5°C at 760 mmHg
• Flash Point: 314.5°C
• Density: 1.51g/cm³
• Vapor Pressure: 3.42E-14mmHg at 25°C
• Refractive Index: 1.788
• CAS DataBase Reference: 9-benzyl-9H-purine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-benzyl-9H-purine-2,6-diamine(7674-36-4)
• EPA Substance Registry System: 9-benzyl-9H-purine-2,6-diamine(7674-36-4)

Safety Data

• Hazardous Substances Data: 7674-36-4(Hazardous Substances Data)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 60598-48-3 5-amino-1-benzyl-1H-imidazole-4-carbonitrile 
• 1839-18-5 2-chloroadenine 
• 5451-40-1 2,6 dichloropurine 
• 6336-42-1 2-amino-9-benzyl-6-chloro-9H-purine 
• 100-39-0 benzyl bromide 
• 10310-21-1 2-Amino-6-chloropurin 
• 1904-98-9 2,6-diaminopurine 
• 68462-61-3 ethyl 5‐amino‐1‐benzyl‐1H‐imidazole‐4‐carboxylate 
• 228263-00-1 9-benzyl-2,6-bis(ethoxycarbonyl)purine 
• 228262-99-5 5-amino-1-benzyl-4-imidazolecarboxylic acid 
• 56046-25-4 6-amino-9-benzyl-2-chloropurine 

Downstream Products

• 226908-43-6 2-amino-9-benzyl-8-hydroxyadenine 
• 226908-04-9 2,6-diamino-9-benzyl-8-bromopurine 
• 328378-73-0 6-Amino-9-benzyl-3-{2-[(diisopropyloxyphosphoryl)methoxy]ethyl}-9H-purin-2(3H)-one 
• 328378-72-9 9-Benzyl-2{2-[(diisopropyloxyphosphoryl)methoxy]ethoxy}-9H-purin-6-amine 
• 226908-63-0 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine 
• 226907-93-3 6-Amino-9-benzyl-2-butylaminopurine 
• 7674-33-1 6-Amino-9-benzyl-9H-purin-2(3H)-one 

Relevant articles and documents

8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide

2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified.

Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: Discovery of 8-mercaptoadenines as potent interferon-inducers

Recently, we have identified 9-benzyl-8-hydroxyadenines bearing an appropriate substituent (a butoxy, propylthio or butylamino group) at the 2-position as potent interferon (IFN)-inducers. Herein we report the design, synthesis, and IFN-inducing activity of 8-substituted 9-benzyladenines possessing such an appropriate substituent at the 2-position. Introduction of the appropriate substituent into the 2-position of the adenine nucleus gave rise to expression of the activity even in 9-benzyladenines bearing no hydroxyl group at the 8-position. An amino group at the 6-position and a hydroxyl or thiol group carrying an acidic proton at the 8-position are required to express excellent IFN-inducing activity. 9-Benzyl-2-butoxy-8-mercaptoadenine (9) indicated the most potent activity with MEC of 0.001 μM.

Heterocyclic compounds

The present invention relates to a heterocyclic compound of the following general formula (I): wherein X is sulfur atom, oxygen atom or —NR3— (R3may form a heterocyclic ring or a substituted heterocyclic ring with R1via the nitrogen atom), R1is alkyl group, substituted alkyl group, aryl group, substituted aryl group, heterocyclic group or substituted heterocyclic group, and R2is hydrogen atom, halogen atom etc.; or its pharmaceutically acceptable salt and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases comprising the compound (I) or its pharmaceutically acceptable salt as active ingredients.