7674-99-9

Upstream product

• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 141-97-9 ethyl acetoacetate 
• 106-51-4 p-benzoquinone 
• 63262-06-6 1,4-dibromo-2,5-diiodobenzene 

Downstream Products

• 1387444-67-8 (E)-diethyl 2-methyl-6-(4-nitrostyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-68-9 (E)-diethyl 2-methyl-6-(4-methylstyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-69-0 (E)-diethyl 2-(4-methoxystyryl)-6-methylbenzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-70-3 (E)-diethyl 2-(4-fluorostyryl)-6-methylbenzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-71-4 (E)-diethyl 2-(4-chlorostyryl)-6-methylbenzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-72-5 (E)-diethyl 2-(4-bromostyryl)-6-methylbenzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-76-9 diethyl 2-methyl-6-((1E,3E)-4-phenylbuta-1,3-dienyl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-77-0 diethyl 2,6-di((E)-styryl)benzo[1,2-b:4,5-b’]difuran-3,7-dicarboxylate 
• 1387444-78-1 (E,E)-diethyl 2,6-bis(4-nitrostyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-79-2 (E,E)-diethyl 2,6-bis(4-methylstyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-80-5 (E,E)-diethyl 2,6-bis(4-methoxystyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-81-6 (E,E)-diethyl 2,6-bis(4-fluorostyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-82-7 (E,E)-diethyl 2,6-bis(4-chlorostyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 
• 1387444-83-8 (E,E)-diethyl 2,6-bis(4-bromostyryl)benzofuro[5,6-b]furan-3,7-dicarboxylate 

Relevant academic research and scientific papers

Synthesis, discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors

A series of benzofuran derivatives were synthesized and evaluated against HUVEC proliferation. Among these compounds, compound 32 exhibited good inhibitory activity and remarkable selectivity to HUVEC. Our current data suggested that array order of methyl, acrylate and carboxylate groups in benzofuran scaffold is the basic requirement for inhibitory activity against HUVEC proliferation. These results demonstrated that benzofuran scaffold represents a promising structural core to discover a new class of active and selective angiogenesis inhibitors.

CuI-catalyzed domino process to 2,3-disubstituted benzofurans from 1-bromo-2-iodobenzenes and β-keto esters

(Chemical Equation Presented) CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with β-keto esters in THF at 100°C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C-C bond formation and a subsequent intramolecular C-O bond formation process. Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes.