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Upstream product

• 58607-90-2 5-oxo-2-pyrazoline-3-carboxylic acid,ethyl ester 
• 59824-69-0 1,6-dimethyl-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 4692-99-3 6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 
• 2941-78-8 2-Amino-5-methylbenzoic acid 

Relevant academic research and scientific papers

4-Alkyl-pyrazolo[5,1-b]-quinazolin-9(4H)-ones and anti-allergic compositions containing them

Certain pyrazolo[5,1-b]quinazolin-9(4H)-ones are disclosed. These compounds prevent the allergic response in mammals.

Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.