76746-18-4Relevant academic research and scientific papers
Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents
Sircar, Jagadish C.,Capiris, Thomas,Kesten, Stephen J.,Herzig, David J.
, p. 735 - 742 (1981)
A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.
