Journal of Medicinal Chemistry p. 735 - 742 (1981)
Update date:2022-08-03
Topics:
Sircar, Jagadish C.
Capiris, Thomas
Kesten, Stephen J.
Herzig, David J.
A new series of antiallergic agents, pyrazolo<5,1-b>quinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazolo<5,1-b>quinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.
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Doi:10.1007/BF00762571
()Doi:10.1039/jr9550002639
(1955)Doi:10.1246/bcsj.53.2610
(1980)Doi:10.1021/jo00324a019
(1981)Doi:10.1039/c5ob01844g
(2015)Doi:10.1021/ic50220a055
(1981)
