Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

Article abstract of DOI:10.1021/jm00138a019

A new series of antiallergic agents, pyrazolo<5,1-b>quinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazolo<5,1-b>quinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.