76751-95-6

Basic information

• Product Name: 6-[(4-methoxyphenyl)carbonyl]-1,3-benzoxazol-2(3H)-one
• CAS NO: 76751-95-6
• Molecular Formula: C₁₅H₁₁NO₄
• Molecular Weight: 269.2521
• Mol File: 76751-95-6.mol
• Article Data: 8

Chemical Properties

• Density: 1.318g/cm³
• Refractive Index: 1.609
• CAS DataBase Reference: 6-[(4-methoxyphenyl)carbonyl]-1,3-benzoxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(4-methoxyphenyl)carbonyl]-1,3-benzoxazol-2(3H)-one(76751-95-6)
• EPA Substance Registry System: 6-[(4-methoxyphenyl)carbonyl]-1,3-benzoxazol-2(3H)-one(76751-95-6)

Safety Data

• Hazardous Substances Data: 76751-95-6(Hazardous Substances Data)

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 99541-49-8 6-(4-Methoxy-benzoyl)-3-(2-methyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 76752-13-1 2-[6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-propionic acid 
• 182325-46-8 3-[6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-propionitrile 
• 169384-96-7 [6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-acetonitrile 
• 99541-52-3 3-(4-Benzyl-piperidin-1-ylmethyl)-6-(4-methoxy-benzoyl)-3H-benzooxazol-2-one 
• 99541-51-2 6-(4-Methoxy-benzoyl)-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 104853-18-1 3-[4-(4-Hydroxy-phenyl)-piperidin-1-ylmethyl]-6-(4-methoxy-benzoyl)-3H-benzooxazol-2-one 
• 99541-50-1 6-(4-Methoxy-benzoyl)-3-(4-methyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 99541-48-7 6-(4-Methoxy-benzoyl)-3-piperidin-1-ylmethyl-3H-benzooxazol-2-one 
• 76752-08-4 2-[6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-propionic acid ethyl ester 
• 76751-98-9 [6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-acetic acid 
• 76752-03-9 3-[6-(4-Methoxy-benzoyl)-2-oxo-benzooxazol-3-yl]-propionic acid 
• 139101-60-3 6-(4-Methoxy-benzoyl)-3-(2-pyridin-4-yl-ethyl)-3H-benzooxazol-2-one 
• 139101-59-0 6-(4-Methoxy-benzoyl)-3-(2-pyridin-2-yl-ethyl)-3H-benzooxazol-2-one 

Relevant articles and documents

SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

Synthesis and antibacterial and antifungal properties of thiazolinoethyl-2(3H)-benzoxazolone derivatives. II

Cyano derivatives of 6-acyl-2(3H)-benzoxazolones were reacted with cysteamine HCl in ethanol to give the corresponding 6-acyl-3-thiazolinoethyl-2(3H)-benzoxazolones and their antibacterial and antifungal activities were investigated. The chemical structures were proved by means of their IR and 1H-NMR spectra and elemental analysis. Investigation of antimicrobiaI activity of the compounds was carried out by tube dilution and disc techniques using bacteria (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 and Streptococcus faecalis ATCC 29212) and yeast-like fungi (Candida parapsilosis, C albicans, C pseudotropicalis and C stellatoidea). Inhibitory effects were observed for many compounds against S aureus and Bacillus subtilis. Compounds 13 and 15 had minimum inhibitory concentrations (MIC) of 8.4 and 4.2 μg/mL respectively. The antifungal studies against C albicans (10 and 16, MIC = 67.5 μg/mL), C parapsilosis (15, MIC = 67.5 μg/mL) and C stellaatoidea (9, MIC = 67.5 μg/mL) were more successful in comparison.

CATALYTIC ACYLATION OF BENZOXAZOLIN-3-ONES IN THE PRESENSCE OF ZINC CHLORIDE

In the acylation of benzoxazolin-2-ones by aromatic acid chlorides in the presence of 10-2 mole ZnCl2, the yields of the corresponding 6-aroylbenzoxazolin-2-ones depend on the electronegativity of the acylating agent and the nucleophilicity of