767614-75-5Relevant academic research and scientific papers
A short asymmetric synthesis of 2,5-disubstituted pyrrolidines
Katritzky, Alan R.,Cui, Xi-Lin,Yang, Baozhen,Steel, Peter J.
, p. 1697 - 1700 (2007/10/03)
A novel approach to chiral 2,5-disubstituted pyrrolidines, starting from chiral 2-phenyl-glycimol, 1,5-dimethoxytetrahydrofuran, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield.
A Stereocontrolled Organopalladium Route to 2,5-Disubstituted Pyrrolidine Derivatives. Application to the Synthesis of a Venom Alkaloid of the Ant Species Monomorium latinode
Baeckvall, Jan-E.,Schink, Hans E.,Renko, Z. Dolor
, p. 826 - 831 (2007/10/02)
A general method for the preparation of cis- and trans-2,5-disubstituted pyrrolidines from conjugated dienes has been developed.The approach involves a stereocontrolled syn- or anti-1,4-addition of an amino and an oxygen function to the diene via palladiu
