767623-85-8

Upstream product

• 10218-04-9 1-methyl-norbornan-2-one 
• 31502-30-4 (+/-)-2-(formylamino)-1-methylbicyclo<2.2.1>heptane 

Downstream Products

• 156473-09-5 [(S)-1-((1S,2R,4R)-1-Methyl-bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 156473-10-8 [(S)-1-((1R,2S,4S)-1-Methyl-bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 156473-12-0 (1S,2R,4R)-2-amino-1-methylbicyclo<2.2.1>heptane 
• 88798-96-3 (1R,2S,4S)-2-amino-1-methylbicyclo<2.2.1>heptane 
• 88798-96-3 endo-2-amino-1-methylbicyclo<2.2.1>heptane 

Relevant academic research and scientific papers

Novel Potassium-Channel Openers: Preparation and Pharmacological Evaluation of Racemic and Optically Active N-(6-Amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine Derivatives

The previous paper reported on the synthesis and pharmacological evaluation of N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives, from among which three compounds were selected as potent potassium-channel openers. In the present study, selected compounds were tested for antagonism of potassium-induced contraction of rat aorta, hypotensive activity in normotensive rats, and diuretic activity in spontaneously hypertensive rats. This led to further evaluation of compound (+/-)-10 and selection of (+)-N-(6-amino-3-pyridyl)-N'-hept-2-yl>-N"-cyanoguanidine ((+)-10) (AL0670) for development as an antihypertensive agent. Although AL0670 is regarded as a pinacidil-type K+-channel opener, it showed different pharmacological and conformational profiles from pinacidil.