767630-86-4

Usage

Also known as

Azepan-1-yl benzoate

Main properties

benzaldehyde derivative

Contains

six-membered azepan-1-yl (hexylamine) moiety, 2-oxoethoxy group

Uses

organic synthesis, pharmaceutical research

Potential applications

development of new drugs and pharmaceuticals

Versatility

suitable for various reactions and derivatization

Upstream product

• 52227-33-5 2,3,4,5,6,7-hexahydro-1-(2-chloro-ethanoyl]-1H-azepine 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 198480-21-6 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole 

Relevant academic research and scientific papers

Industrial production method for bazedoxifene acetate

The invention discloses an industrial production method for bazedoxifene acetate. The production method comprises the following steps: taking p-hydroxy benzaldehyde as a starting material, substituting with chloracetyl-hexamethyleneimine, reducing with borohydride and chlorinating with a chlorinating agent to obtain a compound 4; reacting the compound 4 with 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole to obtain a compound 5; and carrying out debenzylation to obtain a compound 6, and salifying with acetic acid to obtain a target compound which is the bazedoxifene acetate. The defective workmanship of preparation in the prior art is solved, the used reagent is low in cost and easy to obtain, environmental pollution is small, safety is high, an operation process is simple, and thus, the bazedoxifene acetate is suitable for being produced industrially.

Processes for the preparation of aminoethoxybenzyl alcohols

The present invention provides processes and intermediates for the preparation of aminoethoxybenzyl alcohols of Formula I useful in the production of pharmaceutically useful compounds.