76765-82-7

Upstream product

• 6926-51-8 5-(4-methoxyphenyl)-1H-tetrazole 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 76765-91-8 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(2-ethoxyphenyl)thiosemicarbazide 
• 76766-21-7 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(2-ethoxyphenyl)-s-triazol-3-thiol 
• 76765-92-9 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(4-chlorophenyl)thiosemicarbazide 
• 76765-90-7 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(3,4-dimethylphenyl)thiosemicarbazide 
• 76765-88-3 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(2-tolyl)thiosemicarbazide 
• 76776-81-3 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(4-tolyl)thiosemicarbazide 
• 76765-89-4 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-(3-tolyl)thiosemicarbazide 
• 76766-20-6 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(3,4-dimethylphenyl)-s-triazol-3-thiol 
• 76766-22-8 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(4-chlorophenyl)-s-triazol-3-thiol 
• 76765-87-2 1-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylacetyl>-4-phenylthiosemicarbazide 
• 76766-17-1 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(2-tolyl)-s-triazol-3-thiol 
• 76766-19-3 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(4-tolyl)-s-triazol-3-thiol 
• 76766-18-2 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-(3-tolyl)-s-triazol-3-thiol 
• 76766-16-0 5-<5-(4-methoxyphenyl)-2H-tetrazol-2-ylmethyl>-4-phenyl-s-triazol-3-thiol 

Relevant academic research and scientific papers

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Catalytic Synthesis of 5-Substituted Tetrazoles: Unexpected Reactions and Products

Tetrazoles are incredibly useful organic molecules with a wide range of applications from medicinal chemistry as carboxylic acid isosteres to high energy density materials in space research. In an effort to develop an easy protocol for the synthesis of te

Synthesis of 5-Aryl-2H-tetrazoles, 5-Aryl-2H-tetrazole-2-acetic Acids, and acetic Acids as Possible Superoxide Scavengers and Antiinflammatory Agents

A series of 5-aryl-2H-tetrazoles, 5-aryl-2H-tetrazole-2-acetic acids, and acetic acids were synthesized and tested in vitro for superoxide scavenging activity, in vivo in the carrageenan-induced rat paw edema assay, and in the reverse passive Arthus reaction.The hydroxy-substituted compounds were effective as in vitro scavengers of superoxide but were not effective as in vivo antiinflammatory agents.