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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5H,6H,7H-cyclopenta[d]pyrimidin-4-amine is used as a building block for the synthesis of various pharmacologically active compounds. Its unique structure and reactivity make it a valuable intermediate in the development of new drugs.
Used in Agricultural Industry:
2-Chloro-5H,6H,7H-cyclopenta[d]pyrimidin-4-amine is used as a building block for the synthesis of various agrochemicals. Its potential applications in this industry can contribute to the development of new and effective pesticides or other agricultural chemicals.
Used in Drug Discovery and Development:
2-Chloro-5H,6H,7H-cyclopenta[d]pyrimidin-4-amine may have biological activity and could be a valuable tool for drug discovery and development. Further research and studies are needed to explore its full potential and applications in this field.

Upstream product

• 5466-43-3 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 18227-09-3 2-ureido-1-carbethoxycyclopent-1-ene 
• 5466-00-2 6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diol 

Relevant academic research and scientific papers

Cephalosporin compounds

The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which possess potent and broad antibacterial activities. The compounds of the present invention have a (4-amino-1-substituted-alkapyrimidinium-4-yl)thiomethyl group in 3-position of the cephem nucleus and is specifically represented by the following formula(I): STR1 wherein: R 1 is a hydrogen atom or a C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl or --C(R A)(R B)COOH group wherein R A and R B are independently a hydrogen atom or a C 1-4 alkyl group, or form a C 3-7 cycloalkyl group together with the carbon atom to which they are attached;R 2 is an unsubstituted or substituted amino, C 1-4 alkyl or C 3-7 cycloalkyl group; andn is an integer ranging from 2 to 7.

Synthesis and antimicrobial activity of novel 3- [(aminopyrimidiniumyl)thio]methyl cephalosporins

A series of novel cephalosporin compounds which have 3- [(aminopyrimidiniumyl)thio]methyl substituents was synthesized. They show high antimicrobial activity against various bacterial species including Pseudomonas aeruginosa. Structure-activity relationships with various thiopyrimidines, thiopyrimidiniums, bicyclic thiotriazolopyrimidiniums, and bicyclic thioimidazolopyrimidiniums as 3'-substituents were also studied; cephalosporins with quarternized pyrimidinium moieties have better antimicrobial activities than neuteral pyrimidine cephalosporins, and stabilization of the positive charge on the pyrimidinium moieties is essential for better activity. According to semiempirical PM3 calculations, amino and alkylthio substituents on the pyrimidinium rings play a major role in charge stabilization and delocalization.

Novel cephalosporin compounds

The present invention relates to novel cephalosporin compounds, pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof which possess potent and broad antibacterial activities. The compounds of the present invention have a (4-amino-1-substituted-alkapyrimidinium-4-yl)thiomethyl group in 3-position of the cephem nucleus and is specifically represented by the following formula(I): wherein: R1 isa hydrogen atom or, a C1 4 alkyl, C2 4 alkenyl, C2 4 alkynyl or -C(RA)(RB)COOH group wherein RAand RBare independently a hydrogen atom or a C1 4 alkyl group, or form a C3 7 cycloalkyl group together with the carbon atom to which they are attached; R2 isan unsubstituted or substituted amino, C1 4 alkyl or C3 7 cycloalkyl group; and n isan integer ranging from 2 to 7.

Pyrimidine derivatives I. Synthesis of hypoglycemic 2-piperazino-5,6-polymethylenepyrimidines 5,6-polymethylenepyrimidines

Synthesis and hypoglycemic activity of 36 novel 2,4-diamino-5,6-polymethylenepyrimidine derivatives are described. Derivatives containing piperazino groups at position 2 showed a potent hypoglycemic activity and concomitantly inhibited platelet aggregation.