76785-92-7Relevant academic research and scientific papers
REARRANGEMENTS INITIATED BY TRIMETHYLSILYL IODIDE: THE FACILE RING OPENING OF SOME CYCLOBUTANONE DERIVATIVES
Miller, R. D.,McKean, D. R.
, p. 2639 - 2642 (1980)
The powerful electrophile trimethylsilyl iodide in presence of certain catalysts rapidly and cleanly initiates the ring opening of a variety of cyclobutanone derivatives in a highly regioselective fashion yielding ultimately β-iodoketones.
An efficient and general approach to β-functionalized ketones
Jingliang, Jiao,Nguyen, Larry X.,Patterson, Dennis R.,Flowers II, Robert A.
, p. 1323 - 1326 (2008/01/01)
Figure presented The oxidation of selected anlons (N3 -, SCN-, I-, and Br-) by eeric ammonium nitrate (CAN) in the presence of substituted cyclopropyl alcohols provides a novel approach to β-functionalized ketones. The protocol has a number of advantages including short reaction times, ease of reagent handling, and mild, neutral reaction conditions. Overall, this method provides an alternative pathway to important starting materials and intermediates in organic synthesis.
