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Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-4',5,7-trimethoxyflavane is used as a therapeutic agent for its potential antioxidant, anti-inflammatory, and anti-cancer properties. It may help in the treatment of various diseases and conditions by reducing oxidative stress, inflammation, and cancer cell proliferation.
Used in Neuroprotective Applications:
3-Hydroxy-4',5,7-trimethoxyflavane is used as a neuroprotective agent to protect the nervous system from damage and degeneration. Its antioxidant and anti-inflammatory properties may help in the prevention and treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.
Used in Cardiovascular Health Applications:
3-Hydroxy-4',5,7-trimethoxyflavane is used to promote cardiovascular health due to its potential to improve blood flow, reduce inflammation, and protect the heart from oxidative stress. It may help in the prevention and treatment of cardiovascular diseases such as atherosclerosis, hypertension, and heart failure.
Used in Nutraceutical Industry:
3-Hydroxy-4',5,7-trimethoxyflavane is used as a nutraceutical ingredient in dietary supplements and functional foods to provide health benefits beyond basic nutrition. Its antioxidant, anti-inflammatory, and other bioactive properties may contribute to overall health and well-being.
Used in Cosmetic Industry:
3-Hydroxy-4',5,7-trimethoxyflavane is used in cosmetic products for its potential skin health benefits. Its antioxidant and anti-inflammatory properties may help in the prevention of skin aging, protection against environmental stressors, and improvement of skin appearance.
Overall, 3-Hydroxy-4',5,7-trimethoxyflavane is a versatile compound with potential applications in various industries, including pharmaceutical, neuroprotective, cardiovascular health, nutraceutical, and cosmetic industries. Its diverse biological activities and health benefits make it a promising candidate for further research and development.

Upstream product

• 77-78-1 dimethyl sulfate 
• 41515-76-8 (2R,3R)-2,3-dihydro-3,5-dihydroxy-7,4'-dimethoxyflavone 
• 76436-29-8 2-Hydroxy-4,6-dimethoxy-benzoic acid 2-hydroxy-3-(2-hydroxy-4,6-dimethoxy-phenyl)-1-(4-methoxy-phenyl)-3-oxo-propyl ester 
• 26207-83-0 (+/-)-3t-hydroxy-2r-(4-hydroxy-phenyl)-5,7-dimethoxy-chroman-4-one 
• 104435-35-0 tetrakis(methoxymethoxy)isosalipurpol Epoxide 
• 118160-11-5 tetrakis(methoxymethoxy) isosalipurpol 
• 186581-53-3 diazomethane 
• 480-20-6 Aromadendrin 
• 118333-31-6 (2S,3S)-3,40,5,7-tetrahydroxyflavanone 
• 480-20-6 (+/-)-aromadendrin 

Downstream Products

• 118205-75-7 (2R,3S,4S)-(+)-5,7,4'-trimethoxyflavan-3,4-diol 
• 118205-74-6 (2R,3S,4R)-(+)-5,7,4'-trimethoxyflavan-3,4-diol 
• 29063-52-3 (2R^*,3S^*,4S^*)-5,7,4'-trimethoxyflavan-3,4-diol 
• 29063-52-3 (2R^*,3S^*,4R^*)-5,7,4'-trimethoxyflavan-3,4-diol 
• 16692-52-7 3,4',5,7-tetramethoxyflavone 
• 15486-34-7 5-hydroxy-3,4',7-trimethoxyflavone 
• 15486-33-6 4',7,-di-O-methylkaempferol 
• 1098-92-6 kaempferol 5,7,4'-trimethyl ether 
• 57601-13-5 2'-hydroxy-4,α,4',6'-tetramethoxy-chalcone 
• 20754-50-1 (2R)-3t,5,7-trimethoxy-2r-(4-methoxy-phenyl)-chroman-4-one 
• 76733-23-8 3-acetoxy-4',5,7-tri-O-methylaromadendrin 

Relevant academic research and scientific papers

Stereoselective synthesis of flavonoids. Part 4. Trans- and cis-dihydroflavonols

Epoxidation of a series of poly-oxygenated chalcones with H2O2 in the presence of poly-α-aminoacids yielded chiral aromatic oxygenated oxiranes in moderate to high optical yields. Lewis acid-catalysed phenylmethanethiol ringopening o

The first enantioselective synthesis of trans- and cis-dihydroflavonols

Epoxidation of a series of polyoxygenated chalcones with H2O2 in the presence of poly(α-amino acid) catalysts, followed by Lewis acid-catalysed phenylmethanethiol ring-opening and cyclization, afforded trans- and cis-dihydroflavonols

Heterocycles. XXII. Stereoselective Synthesis of (+)-Aromadendrin Trimethyl Ether and Its Enantiomer, and Their Reduction

Two enantiomeric chalcone epoxides 2a and 2b are synthesized under phase-transfer conditions using 1-benzylquinidinium chloride and 1-benzylquininium chloride as catalysts, respectively.Stereoselective cyclisation of 2a and 2b, followed by methylation and

HETEROCYCLES. XVIII. SYNTHESIS OF THE RACEMATES OF NATURALLY OCCURRING FLAVONOIDS

Racemic aromadendrin and fustin have been stereoselectively synthesized.Reduction of the O-substituted derivatives of these flavanonols provides the corresponding derivatives of gleditsin, leucopelargonidin and mollisacacidin (leucofisetinidin).

AURAPIN, A NEW DIHYDROFLAVONOL GLYCOSIDE AND OTHER FLAVONOIDS FROM ACINOS ALPINUS

A new dihydroflavonol glycoside has been isolated from Acinos alpinus and identified as 3-O-rhamnosyl-5-hydroxy-7,4'-dimethoxyflavanone on the basis of chemical and spectroscopic evidence.Three known flavonoids (naringenin, taxifolin and neoponcirin) were additionally isolated from same source.

Some Novel Photochemical and Related Aryl Couplings and Migrations in Flavonoid Synthesis

2'-Methoxymethoxy-4,4',6'-trimethoxychalcone epoxide couples at the β-position with 3,5-dimethoxyphenol under photolytic conditions to form isomeric 1,3,3-triaryl-2-hydroxypropiophenones.These propiophenones are subject to photo-induced α-ketol rearrangements yielding isomeric 1-hydroxypropan-2-ones.Together these serve as useful synthetic intermediates for 4-arylflavan-3-ones and novel 2-hydroxy-2-arylbenzylbenzofuran-3(2H)-ones and 4-aryl-3-hydroxy-3,4-cis-dihydrocoumarins.The same epoxide reacts ionically under ambient conditions with 2,4,6-trihydroxybenzoic acid to afford a 3-O-benzoylpropiophenone intermediate, which provides novel access to isoflavones in high overall yield.Analogous coupling of phloroglucinol to epoxycinnamates gives diastereoisomeric 3,3-diaryl-2-hydroxypropionates which serve as precursors for 3,4-trans- and 3,4-cis-4-aryl-3-hydroxydihydrocoumarins and thence for 3-aryl- and 3-hydroxycoumarins.