15486-33-6

Usage

Uses

Used in Pharmaceutical Industry:
3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE is used as a therapeutic agent for its potential in treating various diseases, such as cancer and neurodegenerative disorders, due to its antioxidant and anti-inflammatory properties.
Used in Drug Development:
3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE is utilized as a candidate for drug development, given its unique chemical structure and biological activities that may offer novel treatment options for a range of medical conditions.
Used in Research and Development:
3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE is employed as a subject of research to further explore its potential applications in medicine and healthcare, with the aim of discovering new therapeutic approaches and enhancing existing treatments.

InChI:InChI=1/C17H14O6/c1-21-10-5-3-9(4-6-10)17-16(20)15(19)14-12(18)7-11(22-2)8-13(14)23-17/h3-8,18,20H,1-2H3

Upstream product

• 491-54-3 4'-O-methylkaempferol 
• 77-78-1 dimethyl sulfate 
• 1098-92-6 kaempferol 5,7,4'-trimethyl ether 
• 41515-76-8 (+/-)-3t,5-dihydroxy-7-methoxy-2r-(4-methoxy-phenyl)-chroman-4-one 
• 15486-34-7 5-hydroxy-3,4',7-trimethoxyflavone 
• 621-23-8 1,2,3-trimethoxybenzene 
• 94103-36-3 (2E)-1-(2,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 5631-70-9 4',5,7-trimethoxyflavone 
• 16692-52-7 3,4',5,7-tetramethoxyflavone 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 65982-77-6 2-benzoyloxy-1-(2,4,6-trihydroxy-phenyl)-ethanone 

Downstream Products

• 15486-34-7 5-hydroxy-3,4',7-trimethoxyflavone 
• 16692-52-7 3,4',5,7-tetramethoxyflavone 

Relevant academic research and scientific papers

Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates

A strategy for selective mono-, di- and tri-O-methylation of kaempferol, predominantly on the basis of selective benzylation and controllable deacetylation of kaempferol acetates, was developed. From the selective deacetylation and benzylation of kaempferol tetraacetate (1), 3,4′,5,-tri-O-acetylkaempferol (2) and 7-O-benzyl-3,4′5,-tri-O-acetylkaempferol (8) were obtained, respectively. By controllable deacetylation and followed selective or direct methylation of these two intermediates, eight O-methylated kaempferols were prepared with 51-77% total yields from kaempferol.

Total synthesis of kaempferol and methylated kaempferol derivatives

Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I2 oxidative-promoting-cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.