76796-97-9Relevant academic research and scientific papers
Rhenium diazenide ternary complexes with dithiocarbamate ligands: Towards new rhenium radiopharmaceuticals
Cowley, Andrew R.,Dilworth, Jonathan R.,Donnelly, Paul S.,Ross, Susan J.
, p. 73 - 82 (2007)
The reaction of the mono-diazenide core, [ReCl2(NNC 6H4-4-OCH3)(NCCH3)(PPh 3)2], with four equivalents of the sodium or potassium salts of dithiocarbamate (dtc) ligands gives neutral complexes of the formula [Re(NNC6H4-4-OCH3)(dtc)2(PPh 3)]. It is possible to use a wide range of dithiocarbamate ligands (S2CNRR′) with a variety of R groups (R = R′ = methyl, phenyl or ethyl; R = methyl, R′ = phenyl and R = R′ = morpholino). Substitution reactions with dtc ligands on the mono-diazenide derived from 2-hydrazinopyridine, [ReCl2(NNC5H4N)(PPh 3)2, give the analogous complexes, [Re(NNC 6H5N)(dtc)2(PPh3)]. The new complexes have been characterised by a combination of NMR spectroscopy, mass spectrometry and X-ray crystallography. Cyclic voltammetry measurements in dimethyl formamide show that the rhenium diazenido-dtc complexes undergo a quasi-reversible oxidation tentatively assigned to a ReIII/Re IV oxidation. Since the parent complex, [ReCl2(NNC 6H4-4-R)(NCCH3)(PPh3)2] can be prepared directly from perrhenate and readily derivatised with dtc ligands these complexes have potential relevance to the development of new therapeutic rhenium radiopharmaceuticals. This journal is The Royal Society of Chemistry.
