76809-58-0Relevant academic research and scientific papers
Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents
Zhu, Xiong,Fu, Junjie,Tang, Yan,Gao, Yuan,Zhang, Shijin,Guo, Qinglong
, p. 1360 - 1364 (2016/02/23)
A group of podophyllotoxin (PPT) derivatives (7a-j) were synthesized by conjugating aryloxyacetanilide moieties to the 4'-hydroxyl of 4'-demethyl-4-deoxypodophyllotoxin (DDPT), and their anticancer activity was evaluated. It was found that the most potent compound 7d inhibited the proliferation of three cancer cell lines with sub to low micromolar IC50 values. Furthermore, it was demonstrated that 7d induced cell cycle arrest in G2/M phase in MGC-803 cells, and regulated the expression of cell cycle check point proteins, such as cyclin A, cyclin B, CDK1, cdc25c, and p21. Finally, 4 mg/kg of 7d reduced the weights and volumes of HepG2 xenografts in mice. Our findings suggest that 7d might be a potential anticancer agent.
Synthesis and NMR study of 2-[N-(Aryl)carbamoylmethyl]phthalazimum iodides
Dumitra?cu, Florea,Mitan, Carmen Irena,Draghici, Constantin,Cǎproiu, Miron Teodor,Cǎprǎu, Delia,Dumitrescu, Denisa
, p. 309 - 314 (2007/10/03)
2-[N-(Aryl)carbamoylmethyl]phthalazinium iodides 11b-k were obtained, for the first time, by reaction between N-aryl-2-iodoacetamides 9b-k and phthalazine (10). The parent compound 11a was prepared by quaternization of phthalazine with iodoacetamide. The structure of the quaternary salts 11a-k was investigated by NMR experiments, namely HH-COSY, 1H- 13C-COSY and NOE.
