76812-02-7

Upstream product

• 169280-10-8 [4-(cyclopropylcarbonyl)]-α-α-dimethylbenzeneacetic acid ethyl ester 
• 115-46-8 C₁₈H₂₁NO 

Downstream Products

• 153439-41-9 (S)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester 
• 153439-42-0 (R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester 
• 138452-21-8 fexofenadine hydrochloride 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN

A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.

Piperidine derivatives

Pharmaceutically useful compounds of the following formula: STR1 wherein R1 represents hydrogen or hydroxy; R2 represents hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2 ; n is a positive whole integer of from 1 to 5; R3 is --CH3, --CH2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and A and B are individually hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R3 is --CH3 ; and pharmaceutically acceptable acid addition salts thereof.