76823-93-3Relevant academic research and scientific papers
Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiazolyl]guanidine
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, (2008/06/13)
A process for preparing N"-[4-[[(2-cyanoethyl)thiol]methyl]-2-thiazolyl]guanidine which comprises reacting a dihaloacetone with an β-cyanoethylthiol in a two phase solvent system at a pH of 4.5-6.0 to produce a 1-halo-3-(2-cyanoethylthio)propanone and reacting the 1-halo-3-(2-cyanoethylthio) with an amidinothiourea.
2-Guanidinothiazoline compounds, and process for preparing them
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, (2008/06/13)
Novel 2-guanidinothiazoline compounds of the general formula STR1 wherein R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, and the acid addition salts thereof; they are important intermediate compounds for preparing famotidine and thiotidine which are medicaments useful as gastric acid secretion inhibitors.
Histamine H2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities.
Yanagisawa,Hirata,Ishii
, p. 849 - 857 (2007/10/02)
A large number of N-cyano amidine derivatives were prepared as potential histamine H2 receptor antagonists and evaluated for their inhibitory action on histamine-stimulated chronotropic response of isolated right atria from guinea pigs. Several selected c
