76823-94-4

Usage

Uses

Used in Pharmaceutical Industry:
3-(((2-GUANIDINO-4-THIAZOLYL)METHYL)THIO)PROPANIMIDIC ACID METHYL ESTER is used as an impurity in the synthesis of Famotidine (F102250), a histamine H2-receptor antagonist. It plays a crucial role in the development and production of this medication, which is commonly used to treat conditions such as gastric ulcers, gastroesophageal reflux disease (GERD), and other acid-related disorders.
Used in Research and Development:
3-(((2-GUANIDINO-4-THIAZOLYL)METHYL)THIO)PROPANIMIDC ACID METHYL ESTER is also utilized in research and development settings, where it can be studied for its potential applications in various fields, such as medicinal chemistry, drug discovery, and the development of new therapeutic agents. Its unique structure and properties make it an interesting candidate for further investigation and exploration.

InChI:InChI=1/C9H15N5OS2/c1-15-7(10)2-3-16-4-6-5-17-9(13-6)14-8(11)12/h5,10H,2-4H2,1H3,(H4,11,12,13,14)

Upstream product

• 76823-89-7 3-(2-aminothiazol-4-yl-methylthio)propionitrile 
• 76823-92-2 3-<<<2-(S-methylisithioureido)-4-thiazolyl>methyl>thio>propionitrile hydroiodide 
• 76823-90-0 3-<<<2-(3-benzoylthioureido)-4-thiazolyl>methyl>thio>propionitrile 
• 76823-91-1 3-<<(2-thioureido-4-thiazolyl)methyl>thio>propionitrile 
• 67-56-1 methanol 
• 76823-93-3 N''-[4-[[(2-cyanoethyl)thio]methyl]-2-thiazolyl]-guanidine 

Downstream Products

• 77219-55-7 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>-N²-(phenylsulfonyl)propionamidine 
• 76823-97-7 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>-N'-cyanopropionamidine 
• 76824-16-3 3-<2-(diaminomethyleneamino)-4-thiazolylmethylthio>-propionamide 
• 76824-35-6 famotidine 
• 89268-62-2 3,5-bis<2-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>ethyl>-4H-1,2,4,6-thiatriazine 1,1-dioxide 
• 76824-05-0 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>-N²-(phenylsulfonyl)propionamidrazone 
• 76823-88-6 3-[(2-guanidinothiazol-4-yl)methylthio]propionamidoxime 
• 90237-03-9 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>sulfinyl>-N²-sulfamoylpropionamidine 
• 76824-17-4 <3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>propionyl>sulfamide hydrochloride 
• 107880-74-0 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>propionic acid 

Relevant academic research and scientific papers

NOVEL COMPOUND, ORGANIC CATION TRANSPORTER 3 DETECTION AGENT, AND ORGANIC CATION TRANSPORTER 3 ACTIVITY INHIBITOR

[Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound. [Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. ????????R1-R2-R3-R4?????(A)

New-quanidino-thiazol compounds, their preparation, and use as intermediates of famotidine process

New 2-guanidino-thiazol compounds with the general formulas where R° represents an hydrogen atom or an alkyl group of low molecular weight, m = 2 to 7, n = 2 to 4, and being R an alkyl group of low molecular weight and that may contain from one N-alkylsilyl group, that are important intermediates for the famotidine preparation, medically used as inhibitor of the gastric secretion.

2-Guanidinothiazoline compounds, and process for preparing them

Novel 2-guanidinothiazoline compounds of the general formula STR1 wherein R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, and the acid addition salts thereof; they are important intermediate compounds for preparing famotidine and thiotidine which are medicaments useful as gastric acid secretion inhibitors.

Histamine H2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities.

A large number of N-cyano amidine derivatives were prepared as potential histamine H2 receptor antagonists and evaluated for their inhibitory action on histamine-stimulated chronotropic response of isolated right atria from guinea pigs. Several selected c

GUANIDINOTHIAZOLE COMPOUNDS, AND MEDICAL COMPOSITIONS CONTAINING THEM

Novel guanidinothiazole compounds of the general formula STR1 wherein R represents a hydrogen atom or a lower alkyl group, Y represents a sulfur atom or a methylene group, m and n each represents an integer of 1-3, A represents the group shown by STR2 (wh

GUANIDINOTHIAZOLE COMPOUNDS, PROCESS FOR PREPARATION AND GASTRIC INHIBITING COMPOSITIONS CONTAINING THEM

Novel guanidinothiazole compounds of the general formula STR1 wherein R represents a hydrogen atom or a lower alkyl group, R. sub.1 represents an amino group, a lower alkyl group, a halogeno lower alkyl group, a substituted-or unsubstituted-aryl group, a