76833-24-4Relevant academic research and scientific papers
Hydrogenation of 4-Substituted Biphenyls
Minabe, Masahiro,Watanabe, Kousuke,Ayabe, Yooichi,Yoshida, Masaaki,Toda, Takashi
, p. 1745 - 1748 (2007/10/02)
Hydrogenations of 4-hydroxy-(1a), 4-methoxy-, and 4-methylbiphenyls were carried out in the presence of Raney nickel (R-Ni), palladium-on-carbon (Pd-C), or platinum as catalysts under relatively mild conditions.The reaction rates depend primarily on the catalysts and less on the substrates.Hydrogenation with Pd-C or Pt took place predominantly in the phenyl ring, independent of the substituent.On the other hand, hydrogenation with R-Ni caused reduction mainly in the substituted aromatic ring.Hydrogenation of the phenol, 1a, using R-Ni afforded predominantly trans-4-phenylcyclohexanol in preference to the cis isomer, differing from the other reactions examined.
AN EFFICIENT SYNTHESIS OF 1-PHENYL-1-PIPERIDINO-trans-4-METHYLCYCLOHEXANE: UNANTICIPATED TOTAL STEREOSELECTIVITY IN THE CATALYTIC HYDROGENATION OF AN OLEFIN
Vinick, F.J.,Nowakowska, J.,Jung, S.
, p. 741 - 744 (2007/10/02)
A superior synthesis of the title compound, 1-phenyl-1-piperidino-trans-4-methylcyclohexane, is reported.The key step, the catalytic hydrogenation of 1-phenyl-1-piperidino-4-methylenecyclohexane hydrochloride, proceeds with unusual stereospecificity via a
