76835-17-1

Basic information

• Product Name: N-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE
• Synonyms: (3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE;1-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE;1-(3,4-DICHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE;1-(3,4-Dichlorophenyl)piperazineHCl;1-(3,4-Dichlorophenyl)piperazine hydrochloride 98%;1-(3,4-Dichlorphenyl)piperazine HCl;1-(3,4-Dichlorophenyl)piperazine monohydrochloride, 98+%;Piperazine, 1-(3,4-dichlorophenyl)-, dihydrochloride
• CAS NO: 76835-17-1
• Molecular Formula: C10H13Cl3N2
• Molecular Weight: 267.58
• EINECS: 200-589-5
• Product Categories: Piperidines, Piperidones, Piperazines
• Mol File: 76835-17-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 217-220°C
• Boiling Point: 424.8 °C at 760 mmHg
• Flash Point: 210.7 °C
• Appearance: /
• Vapor Pressure: 1.14E-05mmHg at 25°C
• CAS DataBase Reference: N-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE(76835-17-1)
• EPA Substance Registry System: N-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE(76835-17-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 76835-17-1(Hazardous Substances Data)

Usage

Uses

1-(3,4-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of inhibitors that targets Trypanosoma cruzi sterol 14α-demethylase.

InChI:InChI=1/C10H12Cl2N2.ClH/c11-9-2-1-8(7-10(9)12)14-5-3-13-4-6-14;/h1-2,7,13H,3-6H2;1H

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 95-76-1 m,p-dichloroaniline 

Relevant articles and documents

Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors

Rational drug design method has been used to generate 4-arylpiperazine carboxamides in an effort to develop safer, more potent and effective monoamine neurotransmitters reuptake inhibitors. Out of twenty-seven synthesized compounds, compound 9 displayed potent monoamine neurotransmitter reuptake inhibitory activity against HEK cells transfected with hSERT or hNET. A Surflex-Dock docking model of 9 was also studied.

Exploration of substituted arylpiperazine–tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors

In the search for potent dual norepinephrine and dopamine reuptake inhibitors, several substituted arylpiperazine–tetrazoles were designed, synthesized and evaluated for their neurotransmitter reuptake inhibitory activities. Various derivatives exhibited selective and strong neurotransmitter reuptake inhibitory activity. In particular, compounds with a three-carbon linker displayed selective and stronger potency than those with two-carbon and four-carbon linkers. Interestingly, six compounds, 9b, 9c, 9d, 9o, 9q and 9u displayed more effective activity than the standard drug, bupropion. The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases.