Bioorganic and Medicinal Chemistry p. 4127 - 4135 (2018)
Update date:2022-08-06
Topics:
Paudel, Suresh
Sun, Ningning
Khadka, Daulat Bikram
Yoon, Goon
Kim, Kyeong-Man
Cheon, Seung Hoon
Rational drug design method has been used to generate 4-arylpiperazine carboxamides in an effort to develop safer, more potent and effective monoamine neurotransmitters reuptake inhibitors. Out of twenty-seven synthesized compounds, compound 9 displayed potent monoamine neurotransmitter reuptake inhibitory activity against HEK cells transfected with hSERT or hNET. A Surflex-Dock docking model of 9 was also studied.
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