768385-14-4Relevant academic research and scientific papers
C-glycosidic UDP-GlcNAc analogues as inhibitors of UDP-GlcNAc 2-epimerase
Stolz, Florian,Blume, Astrid,Hinderlich, Stephan,Reutter, Werner,Schmidt, Richard R.
, p. 3304 - 3312 (2004)
The first step in the biosynthesis of neuraminic acid, the "epimerisation" of UDP-GlcNAc to ManNAc, is catalyzed by UDP-GlcNAc 2-epimerase. In this paper we report the synthesis of the C-glycosidic UDP-GlcNAc analogues 1-5 as substrate-based inhibitors of this enzyme. The focus is on the optimal distance and geometry of the connection between the sugar and the UDP-moiety, which are both important for recognition by UDP-GlcNAc 2-epimerase. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
