76842-84-7Relevant academic research and scientific papers
Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed C[sbnd]H insertion of ethyl diazoacetate into α,β-unsaturated aldehydes
Gandhi, Hirenkumar,O'Sullivan, Timothy P.
supporting information, p. 3533 - 3535 (2017/10/06)
The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct C[sbnd]H insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. C[sbnd]H insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.
Stereoselective synthesis of aryl γ,δ-unsaturated β-hydroxyesters by ketoreductases
Dai, Zhipeng,Guillemette, Kate,Green, Thomas K.
, p. 264 - 269 (2013/10/21)
The biocatalytic reduction of aryl γ,δ-unsaturated-β- ketoesters was evaluated utilizing 24 different commercially available ketoreductases. In all cases, both (R) and (S)-enantiomers of γ,δ-unsaturated β-hydroxyesters were synthesized by one or more keto
Studies on cerebral protective agents. VI. Synthesis of novel 4-(4- nitrobenzoyl)pyrimidine and related compounds with anti-anoxic activity
Ohkubo,Kuno,Sakai,Sugiyama,Takasugi
, p. 1279 - 1285 (2007/10/02)
Novel pyrimidine derivatives, possessing linkages between the aryl group and the pyrimidine nucleus at the C-4 position, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, 5-(4-methylpiperazin-1- ylcarbonyl)-4-(4-nitrobenzoyl)-2-p
ANIONIC ACTIVATION OF STABILIZED YLIDES. A HIGHLY Z-STEREOSELECTIVE WITTIG REACTION OF (3-ETHOXYCARBONYL-2-OXOPROPYLIDENE)TRIPHENYLPHOSPHORANE WITH ALIPHATIC ALDEHYDES
Pietrusiewicz, K. Michal,Monkiewicz, Jaroslaw
, p. 739 - 742 (2007/10/02)
Reaction of stabilized ylide 1 with carbonyl partners can be promoted via anionic activation of the ylide; the presence of charge is responsible for the high Z-selectivity in the direct formation of conjugated enones.
ETHYL 4-DIPHENYLPHOSPHINOYL-3-OXOBUTANOATE: A CONVENIENT REAGENT FOR THE SYNTHESIS OF γ,δ-UNSATURATED Β-KETOESTERS
Goorbergh, J. A. M. van den,Gen, A. van der
, p. 3621 - 3624 (2007/10/02)
Aldehydes and ketones can be converted into γ,δ-unsaturated-β-ketoesters by reaction with the dianion from phosphine oxide 1.
