76849-19-9Relevant academic research and scientific papers
Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin
Hynes,Patil,Tomazic,Kumar,Pathak,Tan,Xianqiang,Ratnam,Delcamp,Freisheim
, p. 449 - 454 (2007/10/02)
A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of thymidylate synthase, TS, from mouse L1210 leukemia cells with 10-propargyl-5,8-dideazafolic acid, CB3717, 4a, as the referenc
Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid
Nair,Salter,Kisliuk,Gaumont,North,Sirotnak
, p. 605 - 607 (2007/10/02)
A close analogue of the antileukemic agent 5,8-dideaza-N10 propargylfolic acid (2) was synthesized by replacing the propargyl moiety of 2 with a cyanomethyl group. This compound, N10-(cyanomethyl)-5,8-dideazafolic acid (3), was evalu
