76849-19-9

Basic information

• Product Name: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid
• Synonyms: ICI-155387; CB-3717; N-[4-[N-[(2-Amino-4-hydroxy-6-quinazolinyl)methyl]prop-2-ynylamino]benzoyl]-L-glutamic acid; N10-Propargyl-5,8-dideazafolic acid; N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}benzoyl)glutamic acid
• CAS NO: 76849-19-9
• Molecular Formula: C₂₄H₂₃N₅O₆
• Molecular Weight: 477.4693
• Mol File: 76849-19-9.mol
• Article Data: 2

Chemical Properties

• Density: 1.41g/cm³
• Refractive Index: 1.666
• CAS DataBase Reference: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid(76849-19-9)
• EPA Substance Registry System: N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid(76849-19-9)

Safety Data

• Hazardous Substances Data: 76849-19-9(Hazardous Substances Data)

Upstream product

• 27069-81-4 N-{4-[(2-amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoyl}-glutamic acid diethyl ester 
• 76858-74-7 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid diethyl ester 
• 76858-74-7 diethyl N¹⁰-propargyl-5,8-dideazafolic acid 
• 76858-72-5 diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate 
• 58677-08-0 2-amino-6-(bromomethyl)-4-hydroxyquinazoline 

Relevant articles and documents

Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin

A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of thymidylate synthase, TS, from mouse L1210 leukemia cells with 10-propargyl-5,8-dideazafolic acid, CB3717, 4a, as the referenc