76858-74-7

Basic information

• Product Name: diethyl N¹⁰-propargyl-5,8-dideazafolic acid
• Synonyms: diethyl N¹⁰-propargyl-5,8-dideazafolic acid
• CAS NO: 76858-74-7
• Molecular Weight: 533.584
• Mol File: 76858-74-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: diethyl N¹⁰-propargyl-5,8-dideazafolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N¹⁰-propargyl-5,8-dideazafolic acid(76858-74-7)
• EPA Substance Registry System: diethyl N¹⁰-propargyl-5,8-dideazafolic acid(76858-74-7)

Safety Data

• Hazardous Substances Data: 76858-74-7(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 27069-81-4 N-{4-[(2-amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoyl}-glutamic acid diethyl ester 
• 58677-08-0 2-amino-6-(bromomethyl)-4-hydroxyquinazoline 
• 76858-72-5 diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate 

Downstream Products

• 76849-19-9 10-propargyl-5,8-dideazafolic acid 
• 100020-44-8 diethyl N-<3-chloro-4-prop-2-ynylamino>benzoyl>-L-glutamate 
• 76849-19-9 10-propargyl-5,8-dideazafolate 
• 100020-40-4 N-<3-chloro-4-prop-2-ynylamino>benzoyl>-L-glutamic acid 

Relevant articles and documents

Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin

A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of thymidylate synthase, TS, from mouse L1210 leukemia cells with 10-propargyl-5,8-dideazafolic acid, CB3717, 4a, as the referenc