76849-27-9Relevant academic research and scientific papers
Studies on pyrazines; part 30: Synthesis of aminopyrazines from azidopyrazines
Sato,Matsuura,Miwa
, p. 931 - 934 (2007/10/02)
Azidopyrazines do not undergo reduction by reagents that are effective for the preparation of alkyl- or arylamines from the azides because the heterocyclic azides exist in the bicyclic form of tetrazolo[1,5-a]pyrazines. Nevertheless, the conversion into aminopyrazines was achieved by hydrogenolysis in the presence of ammonium hydroxide and palladium-on-carbon or particularly by reduction with tin(II) chloride in methanolic hydrochloric acid, in 34-87% yields. To elucidate the successful progress of the reaction, the equilibrium of azide-atetrazole was examined by 1H NMR spectroscopy in various solvents.
Synthesis of Some Alkyl- and Arylimidazoles
Watanabe, T.,Nishiyama, J.,Hirate, R.,Uehara, K.,Inoue, M.,et al.
, p. 1277 - 1281 (2007/10/02)
The pyrolysis of 2-azidopyrazines led to give 1-cyanoimidazoles, which were hydrolyzed in alkaline and acidic media to the corresponding imidazoles.This ring transformation occured also by photolysis.
PYROLYSIS OF AZIDO-DIPHENYLPYRAZINES
Ohta, Akihiro,Watanabe, Tokuhiro,Nishiyama, Junko,Uehara, Kozue,Hirate, Rei
, p. 1963 - 1966 (2007/10/02)
The pyrolysis of 2-azido-3,5- (IIa), 2-azido-3,6- (IIb), and 2-azido-5,6-dipheny;pyrazines (IIc), prepared from the corresponding 2-chloro-diphenylpyrazines and sodium azide, led respectively to 1-cyano-diphenylimidazoles (IIIa, IIIb, and IIIc) in good yi
