41270-72-8

Upstream product

• 76849-27-9 2-azido-3,6-diphenylpyrazine 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 14372-45-3 2-bromo-propionic acid phenacylamide 
• 34046-78-1 2,5-diphenylpyrazine 1-oxide 
• 5398-63-0 2,5-diphenylpyrazine 
• 41270-64-8 2-Chloro-3,6-diphenylpyrazine 
• 60-35-5 acetamide 

Downstream Products

• 1088-34-2 3,6-diphenylpyrazin-2(1H)-one 

Relevant academic research and scientific papers

Studies on pyrazines; part 30: Synthesis of aminopyrazines from azidopyrazines

Azidopyrazines do not undergo reduction by reagents that are effective for the preparation of alkyl- or arylamines from the azides because the heterocyclic azides exist in the bicyclic form of tetrazolo[1,5-a]pyrazines. Nevertheless, the conversion into aminopyrazines was achieved by hydrogenolysis in the presence of ammonium hydroxide and palladium-on-carbon or particularly by reduction with tin(II) chloride in methanolic hydrochloric acid, in 34-87% yields. To elucidate the successful progress of the reaction, the equilibrium of azide-atetrazole was examined by 1H NMR spectroscopy in various solvents.

A SIMPLE METHOD FOR THE PREPARATION OF SOME AMINO N-HETEROAROMATICS

The heating of some halogenated pyrazines, pyridines, and quinolines with benzamide in the presence of potassium carbonate gave the corresponding amino derivatives.The similar reaction using acetamide afforded acetamido derivatives, together with amines in some cases.