76859-81-9

Basic information

• Product Name: Benzene, 1-chloro-4-[2-[(4-methoxyphenyl)sulfonyl]ethenyl]-, (E)-
• CAS NO: 76859-81-9
• Molecular Formula: C15H13ClO3S
• Molecular Weight: 308.785
• Mol File: 76859-81-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-[2-[(4-methoxyphenyl)sulfonyl]ethenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-[2-[(4-methoxyphenyl)sulfonyl]ethenyl]-, (E)-(76859-81-9)
• EPA Substance Registry System: Benzene, 1-chloro-4-[2-[(4-methoxyphenyl)sulfonyl]ethenyl]-, (E)-(76859-81-9)

Safety Data

• Hazardous Substances Data: 76859-81-9(Hazardous Substances Data)

Upstream product

• 130948-55-9 diethyl (((4-methoxyphenyl)thio)methyl)phosphonate 
• 1478586-47-8 diethyl (((4-methoxyphenyl)sulfonyl)methyl)phosphonate 
• 104-88-1 4-chlorobenzaldehyde 
• 6140-09-6 sodium 4-methoxy-benzenesulfonate 
• 1073-67-2 4-vinylbenzyl chloride 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 3937-99-3 p-methoxy-phenylsulphonylacetic acid 

Downstream Products

• 73628-19-0 C₁₆H₁₅ClO₃S 

Relevant articles and documents

Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy

Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited a broad range of activities in inducing HO-1, whose gene expression is under the control of Nrf2. Among them, compound 12g was confirmed to activate Nrf2 and induce expression of the Nrf2-dependent antioxidant enzymes NQO1, GCLC, GLCM, and HO-1, at both mRNA and protein levels in DAergic neuronal cells. This was accompanied by protection of DAergic neurons in both in vitro and MPTP-induced in vivo models of PD. In addition, compound 12g effectively resulted in attenuation of the PD-associated behavioral deficits in the mouse model.

Reactions of Arenesulfonyl Chlorides with Olefins Catalyzed by a Ruthenium(II) Complex

Arenesulfonyl chlorides react with vinylarenes in the presence of dichlorotris(triphenylphosphine)ruthenium(II) catalyst and 1 molar equiv of a tertiary amine to form α,β-unsaturated sulfones 2.Only the E isomers of the sulfones are formed.In reactions of arenesulfonyl chlorides containing an electron-withdrawing Cl or NO2 substituent with α-methylstyrenes, 2-aryl-3-(arylsulfonyl)propenes (5) are also formed.Mechanisms for these reactions are proposed.