7686-98-8

Upstream product

• 7687-04-9 N-(4-benzyloxy-3-methoxy-phenethyl)-2-(6-bromo-benzo[1,3]dioxol-5-yl)-acetamide 

Downstream Products

• 27777-36-2 7-benzyloxy-1-(6-bromo-benzo[1,3]dioxol-5-ylmethyl)-6-methoxy-2-methyl-3,4-dihydro-isoquinolinium; iodide 
• 7686-99-9 (+)-7-benzyloxy-1-(6-bromo-benzo[1,3]dioxol-5-ylmethyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 7686-99-9 (-)-7-benzyloxy-1-(6-bromo-benzo[1,3]dioxol-5-ylmethyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 7686-99-9 7-benzyloxy-1-(6-bromo-benzo[1,3]dioxol-5-ylmethyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 7687-02-7 2-benzyloxy-3-methoxy-9,10-(methylenedioxy)-5,6-dihydroindolo[2,1-a]isoquinoline 
• 7687-03-8 2-benzyloxy-3-methoxy-7ξ-methyl-(13ar)-5,6,13,13a-tetrahydro-[1,3]dioxolo[4',5':5,6]indolo[2,1-a]isoquinolinium; iodide 
• 27675-59-8 7-benzyloxy-1-(6-bromo-benzo[1,3]dioxol-5-ylmethyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 7687-01-6 2-benzyloxy-5,6,12,12a-tetrahydro-3-methoxy-9,10-methylenedioxybenz[b,g]indolizine 

Relevant academic research and scientific papers

Phosphane-free Pd0-catalyzed cycloamination and carbonylation with Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3: Preparation of benzocyclic amines and benzolactams

Phosphane-free Pd0-catalyzed intramolecular aromatic amination was studied. o-Halophenethylamines and 3-(o-halophenyl)propylamines were found to be transformed into indolines and quinolines in a catalytic system based on Pd(OAc)2 and Cu(OAc)2 in the presence of K 2CO3. Application of the method to substrates containing isoquinoline rings- the 1-(o-bromobenzyl)-3,4-dihydroisoquinolines 6, the 1-(o-bromobenzyl)-1,2,3,4-tetrahydroisoquinolines 7, and the 1-(o-bromophenethyl)isoquinolines 9- provided the indolo[2,1-a]isoquinoline and dibenzo[a,f]quinolizine ring systems 8 and 10. Extension of the method to β-carbolines (compounds 11, 12, and 17) produced the benz[f]indolo[2,3-a] indolizine-13-ones 15 and the benz[f]indolo[2,3-a]quinolizine 18. The benzo[f]pyrido[3,4-a]indolizine and indolo[f]pyrido[3,4-a]indolizin-12-one ring systems 27 and 31 were built in a similar manner. It was also found that under an atmosphere of CO the same catalytic system produced the corresponding benzolactams, the isoquino[2,1-a][2,7]naphthyridine 34 and the indolo[2,3-a]pyrido[g]quinolizin-8-one 36 [(±)-dihydronauclefine] in good yields. Copyright

(±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners

C1 and flexible analogs of (±)-nantenine were synthesized and evaluated for antagonist activity at human 5-HT2A receptors in a calcium mobilization assay. This work has resulted in the identification of the most potent 5-HT2A antagon