76869-07-3Relevant articles and documents
Derivatives of 2-phenylindole and carbazole as host materials for phosphorescent organic light emitting diodes
Keruckiene, Rasa,Volyniuk, Dmytro,Ostrauskaite, Jolita,Peciulyte, Laura,Grazulevicius, Juozas V.,Kostjuk, Sergei V.,Lazauskas, Algirdas
, p. 58 - 68 (2017)
Synthesis and thermal, electrochemical, photophysical and charge-transporting properties of the derivatives of carbazole and 2-phenylindole are reported. Compounds with reactive functional groups are emphasized. Two compounds form molecular glasses with t
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells
Sherer, Christopher,Tolaymat, Ibrahim,Rowther, Farzana,Warr, Tracy,Snape, Timothy J.
supporting information, p. 1561 - 1565 (2017/03/16)
The prognosis for glioblastoma patients is, at best, poor, with the median time of survival after diagnosis measured in months. As such, there is much need for the rapid development of potent and novel treatments. Herein, we report our preliminary findings on the SAR of a series of indole-3-carbinol and related fragments and reveal a potent lead with low micromolar activity against a particularly resistant glioblastoma cell culture, providing a new platform for future development of a new therapy in this area.
INDOLE DERIVATIVES
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Paragraph 00170, (2014/04/17)
The present invention relates to compounds for use as therapeutic agents, particularly in the treatment and/or prevention of proliferative disorders, such as cancer, especially brain cancers/tumours, wherein the compounds are generally defined by the form
Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma
Prabhu, Saurabh,Akbar, Zaheer,Harris, Frederick,Karakoula, Katherine,Lea, Robert,Rowther, Farzana,Warr, Tracy,Snape, Timothy
, p. 1918 - 1924 (2013/05/08)
A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell viability after treatment with the compounds. The best indoles,