50615-06-0Relevant academic research and scientific papers
Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells
Sherer, Christopher,Tolaymat, Ibrahim,Rowther, Farzana,Warr, Tracy,Snape, Timothy J.
supporting information, p. 1561 - 1565 (2017/03/16)
The prognosis for glioblastoma patients is, at best, poor, with the median time of survival after diagnosis measured in months. As such, there is much need for the rapid development of potent and novel treatments. Herein, we report our preliminary findings on the SAR of a series of indole-3-carbinol and related fragments and reveal a potent lead with low micromolar activity against a particularly resistant glioblastoma cell culture, providing a new platform for future development of a new therapy in this area.
Derivatives of 2-phenylindole and carbazole as host materials for phosphorescent organic light emitting diodes
Keruckiene, Rasa,Volyniuk, Dmytro,Ostrauskaite, Jolita,Peciulyte, Laura,Grazulevicius, Juozas V.,Kostjuk, Sergei V.,Lazauskas, Algirdas
, p. 58 - 68 (2016/10/11)
Synthesis and thermal, electrochemical, photophysical and charge-transporting properties of the derivatives of carbazole and 2-phenylindole are reported. Compounds with reactive functional groups are emphasized. Two compounds form molecular glasses with t
Synthesis and antibacterial evaluation of 3,3′-diindolylmethane derivatives
Roy, Sutapa,Gajbhiye, Rahul,Mandal, Madhumita,Pal, Churala,Meyyapan, Arumugam,Mukherjee, Joydeep,Jaisankar, Parasuraman
, p. 1371 - 1377 (2014/03/21)
Various 3,3′-diindolylmethane (DIM) derivatives were synthesized and the antibacterial activity of these compounds were tested against ten bacterial strains and their minimum inhibitory concentration (MIC) values were determined. The MIC values of derivatives 3a-d and 5a-e were ranging from 125 to 500 μg/mL. Among these derivatives, 2-(di(1H-indol-3-yl)methyl)phenol (5a) and 3-((1H-indol-3-yl)(pyridin-3-yl)methyl)-1H-indole (5d) exhibited potent activity, showing MIC values 6.5-62.5 μg/mL against Gram positive and Gram negative bacteria. Hemolytic assay of these active DIM derivatives did not show considerable toxic effect on the normal human erythrocytes.
Green protocol for the synthesis of bisindolylmethanes and evaluation of their antimicrobial activities
Tiwari, Anjali,Jain, Meenakshi
experimental part, p. 2835 - 2845 (2010/05/18)
A simple, efficient, and ecofriendly procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of 2-phenylindoles with aldehydes is described. The reaction takes place in the presence of glacial acetic acid and a catalytic amount of anhydrous ferric chloride. All the synthesized compounds have been characterized by elemental analysis and spectral data (IR and 1H NMR). They have also been evaluated for their antibacterial and antifungal activities, and some of them have shown promising results against S. aureus, E. coli, A. flavus, and A. niger.
Eco-friendly synthesis and study of new plant growth promoters: 3,3′-Diindolylmethane and its derivatives
Pal, Churala,Dey, Sumit,Mahato, Sanjit Kumar,Vinayagam, Jayaraman,Pradhan, Prasun K.,Giri, Venkatachalam Sesha,Jaisankar, Parasuraman,Hossain, Tanvir,Baruri, Shikhi,Ray, Debjit,Biswas, Suparna Mandal
, p. 4924 - 4928 (2008/02/11)
3,3′-Diindolylmethane (DIM) derivatives 3a-k, prepared in one-pot from indoles 1a-k and hexamethylenetetramine (2) using ionic liquid [Bmim]BF4 as eco-friendly recyclable solvent as well as catalyst, showed good plant growth promoting activity on Oryza sativa. Among the DIM derivatives synthesized 3c shows potent auxin like growth promoting activity.
InCl3-HMTA as a methylene donor: One-pot synthesis of diindolylmethane (DIM) and its derivatives
Pradhan, Prasun K.,Dey, Sumit,Giri, Venkatachalam Sesha,Jaisankar, Parasuraman
, p. 1779 - 1782 (2007/10/03)
Treatment of indoles la-k with hexamethylenetetramine (HMTA) (2) in presence of a catalytic amount (10 mol%) of InCl3 resulted in 3,3′-diindolylmethane (DIM) derivatives 3a-k in excellent yields. Georg Thieme Verlag Stuttgart.
Radical intermediates in the peroxidation of indoles
Astolfi,Greci,Rizzoli,Sgarabotto,Marrosu
, p. 1634 - 1640 (2007/10/03)
2-Substituted and 1,2-disubstituted indoles react with m-chloroperbenzoic acid and hydrogen peroxide in the presence of acid or calcium chloride affording 2- and 3-(3-oxoindol-2-yl)indoles; whereas 2,3-disubstituted indoles, reacting with the same oxidant
Mannich Reactions Of Indoles With Dichloromethane And Secondary Amines Under High Pressure
Matsumoto, Kiyoshi,Uchida, Takane,Hashimoto, Shiro,Yonezawa, Yukie,Iida, Hirokazu,et al.
, p. 2215 - 2220 (2007/10/02)
Mannich reactions of indole with dichloromethane and secondary amines gave the corresponding Mannich bases in moderate to good yields, while 2-methylindole afforded only low yields of the Mannich bases.Some limitations were observed in the cases of hinder
N-Allylation And N-Benzylation Of 2-Phenylindole And Its Condensation With Carbonyl Compounds
Obynochnyi, A. A.,Anisimov, B. N.,Sergeeva, N. D.,Prostakov, N. S.
, p. 553 - 555 (2007/10/02)
By allylation and benzylation of 2-phenyl- and 2-phenyl-3-formylindole, N-allyl- and benzyl-substituted indoles have been obtained.By condensation of 2-phenylindole with 2-formylfluorene, and also with 4-aza- or 3-methyl-2-azafluorenone, compounds containing fragments of the indole, fluorene, and azafluorenone systems have been synthesized.In the interaction of 2-phenylindole or indole with formaldehyde and 2,5-dimethylpiperidin-4-one, depending on the temperature, bis(2-phenylindol-3-yl)methane, (2',5'-dimethyl-4'-oxopiperidino)-(1-indolyl)methane, andbis(indol-3-yl)methane are formed.
