76873-99-9

Upstream product

• 10597-60-1 hydroxytyrosol 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 1346265-61-9 C₂₃H₂₈O₁₂ 
• 106972-94-5 calceolarioside B 

Downstream Products

• 50-99-7 D-glucose 
• 492-62-6 alpha-D-glucopyranose 

Relevant academic research and scientific papers

Dopaol 2-keto- and 2,3-diketoglycosides from Chelone obliqua

Two unique 2-(3,4-dihydroxyphenyl)ethyl glycosides, namely, dopaol β-D-2-ketoglucopyranoside and dopaol β-D-2,3-diketoglucopyranoside, were isolated from Chelone obliqua together with the iridoid glucoside catalpol, dopaol β-D-glucopyranoside, descaffeoylverbascoside, and verbascoside. Glycosides with a diketosugar have not so far been isolated from natural sources.

Comparative study of relationship between structure of phenylethanoid glycopyranosides and their activities using cell-free assays and human cells cultured in vitro

The study focused on protective potential of phytochemicals applicable in prevention and health protection is of great importance. Various structures of these compounds and a wide range of their biological activities have inspired organic chemists to sythesize their effective analogues in order to further increase their efficacy. The aims of our study were (i) to synthesize phenylethanoid glycopyranosides: salidroside (SALI - tyrosol β-D-glucopyranoside), tyrosol β-D-galactopyranoside (TYBGAL), tyrosol α-D-galactopyranoside (TYAGAL), tyrosol α-D-mannopyranoside (TYAMAN), hydroxytyrosol α-D-mannopyranoside (HOTAMA), homosyringyl β-D-glucopyranoside (HSYGLU), hydroxytyrosol β-D-xylopyranoside (HOTXYL) and hydroxysalidroside (HOSALI); (ii) to determine their antioxidant capacities (cell-free approaches); (iii) to evaluate their cytotoxicity (MTT test), protectivity against hydrogen peroxide (H2O2; comet assay) and effect on the intracellular glutathione level (iGSH; flow cytometry) in experimental system utilizing human hepatoma HepG2 cells. HOSALI, HOTAMA, HOTXYL and HSYGLU manifested the highest antioxidant capacity in cell-free assays and they were most active in protection of HepG2 cells against H2O2. On the other hand, pre-treatment of HepG2 cells with SALI had protective effects even though SALI displayed almost no activity in cell-free assays. Differences in the efficacy of the analogues revealed that structures of their molecules in terms of aglycone combined with sugar moiety affect their activities.

Phenethyl alcohol glucoside analogue and its synthetic method and application (by machine translation)

The invention discloses phenethyl alcohol glucoside analogue and its synthetic method and application. The invention uses biological electronic isostere of such drugs design principle obtain a series of a kind of transformation with neuroprotective activity of the phenethyl alcohol glucoside derivative, sialic acid methyl ester derivatives and 9 the methcoside [...] decarboxylative rosmarinic acid compounds. The invention further provides a method for synthesizing analogs of phenethyl alcohol glucoside. Nerve pharmacological experimental study found, the breeding invention benzene through like apoptotic, to anti-oxidative damage, increasing the cell survival, reduce the apoptosis rate, inhibiting the production of reactive oxygen species in cells, significantly reducing the damage of the cells, play a neuroprotective role. Phenethyl alcohol glucoside provided by the invention includes analogs in the prevention or treatment of neurodegenerative disease, cerebral ischemia, in neurological disorders has important application potential. (by machine translation)

Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae)

Monoterpenoids (3 and 4), sesquiterpenoid (2), diterpenoid (1) and four phenethyl glucosides (5-8), together with fourteen known compounds, were isolated from the whole herb of Hyssopus cuspidatus. Their structures were determined by spectroscopic means.

Compositions for potentiating glutatthione

A composition for potentiating glutathione, which contains at least one member selected from the group consisting of 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, a plant containing 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, an extract of said plant, a hydrolysate of said plant, and a hydrolysate of the extract of said plant (excluding Olea europaea and an extract thereof), and which further contains at least one member selected from among an S-containing compound that is a supply source of cysteine, a protein that contains cysteine and/or cystine, a yeast that contains cysteine and/or cystine, and a vitamin.

Characterization of Cassanese olive cultivar through the identification of new trace components by ionspray tandem mass spectrometry

Pneumatically assisted electrospray (ionspray) coupled with liquid chromatography was applied in the identification of antioxidants present in traces in the leaves of Olea europea L. cv. Cassanese, a typical olive tree from the northeastern part of Calabria region in Italy. The structures of these potential biomarkers were evaluated with reference to established mass spectrometric rules or, in one case, by matching the tandem mass spectrum of the unknown with that of an authentic sample obtained by synthesis.

PHENYLPROPANOID GLYCOSIDES OF PRUNUS SSIORI

Two new bitter phenylpropanoid glucosides, 2-(3,4-methyllenedioxyphenyl)-ethyl-(6-O-caffeoyl)-β-D-glucopyranoside and 3-O-caffeoyl-β-D-fructofuranosyl, 2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside, have been isolated together with the know compounds, 6-O-caffeoyl-D-glucopyranoside and 2-(3,4-dihydroxyphenyl)-ethyl-(6-O-caffeoyl)-β-D-glucopyranoside, from the bark of Prunus ssiori.The structures of the isolated compounds have been established by extensive spectroscopic studies. - Key words: Prunus ssiori; Rosaceae; bark; phenylpropanoid glucosides; caffeic acid esters.

PHENOLIC GLUCOSIDES FROM PRUNUS GRAYANA

A new bitter phenylpropanoid glucoside, 2-(4-hydroxyphenyl)-ethyl-(6-O-caffeoyl)-β-D-glucopyranoside and a new bitter tannin-related compound, 3,4,5-trimethoxybenzoyl-β-D-glucopyranoside, have been isolated together with known compounds, 2-(3,4-dihydroxyphyenyl)-ethyl-(6-O-caffeoyl)-β-D-glucopyranoside,2-(3,4-dihydroxyphenyl)-ethyl-β-D-glucopyranoside and 6-O-caffeoyl-D-glucopyranose, from the bark of Prunus grayana.The structures of these compounds have been established on the basis of spectroscopic studies and chemical evidence. Key Word Index--Prunus grayana; Rosaceae; phenylpropanoid glucosides; tannin-related compound; caffeic acid esters; 3,4,5-trimethoxybenzoic acid ester.