76875-21-3

Basic information

• Product Name: 2-(3-METHOXY-PHENYL)-1H-IMIDAZOLE
• Synonyms: 2-(3-METHOXY-PHENYL)-1H-IMIDAZOLE
• CAS NO: 76875-21-3
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 76875-21-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 386.4°C at 760 mmHg
• Flash Point: 140.4°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 7.89E-06mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 2-(3-METHOXY-PHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-METHOXY-PHENYL)-1H-IMIDAZOLE(76875-21-3)
• EPA Substance Registry System: 2-(3-METHOXY-PHENYL)-1H-IMIDAZOLE(76875-21-3)

Safety Data

• Hazardous Substances Data: 76875-21-3(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic organic compound

Structure

Contains an imidazole ring with a methoxy group attached to the phenyl ring

Pharmaceutical applications

Potential use as a building block for the synthesis of bioactive molecules

Usage

Chemical research and development, particularly in the field of medicinal chemistry

Biological activities

Exhibits various biological activities

Potential uses

May be involved in the development of new drugs and pharmaceutical products

InChI:InChI=1/C10H10N2O/c1-13-9-4-2-3-8(7-9)10-11-5-6-12-10/h2-7H,1H3,(H,11,12)

Upstream product

• 288-32-4 1H-imidazole 
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• 591-31-1 3-methoxy-benzaldehyde 
• 61161-41-9 2-(3-methoxyphenyl)-4,5-dihydro-1H-imidazole 
• 100-66-3 methoxybenzene 
• 50846-98-5 2-Diazo-2H-imidazole 

Relevant articles and documents

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

Bacterial resistance to antibiotics makes previously manageable infections again disabling and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of the bacterial division process by targeting key protein FtsZ has been recognized as an attractive approach for discovering new antibiotics. Binding of small molecules to the cleft between the N-terminal guanosine triphosphate (GTP)-binding and the C-terminal subdomains allosterically impairs the FtsZ function, eventually inhibiting bacterial division. Nonetheless, the lack of appropriate chemical tools to develop a binding screen against this site has hampered the discovery of FtsZ antibacterial inhibitors. Herein, we describe the first competitive binding assay to identify FtsZ allosteric ligands interacting with the interdomain cleft, based on the use of specific high-affinity fluorescent probes. This novel assay, together with phenotypic profiling and X-ray crystallographic insights, enables the identification and characterization of FtsZ inhibitors of bacterial division aiming at the discovery of more effective antibacterials.

Four-tooth-ring metal palladium (II) complex phosphorescent material

The invention discloses a four-tooth-ring metal palladium (II) complex phosphorescent material represented by a formula (I), wherein a pentabasic heteromatic group Ar is formula (shown in the description) and is selected from one of the following formulae: 2H-1,2,3-triazole, wherein X1 is equal to N, X2 is equal to N, and X3 is equal to CH); 1H-1,2,3-triazole, wherein X1 is equal to CH, X2 is equal to N, and X3 is equal to N; oxazole, wherein X1 is equal to O, X2 is equal to C, and X3 is equal to CH; thiazole, X1 is equal to S, X2 is equal to C, and X3 is equal to CH; or N-methylimidazole, wherein X1 is equal to N-Me, X2 is equal to C, and X3 is equal to CH). The four-tooth-ring metal palladium (II) complex phosphorescent material is strong in molecular rigidity, capable of effectively reducing energy consumed by molecular vibration, high in phosphorescent quantum efficiency and good in chemical stability and thermal stability and can be applied to luminescent layers of organic luminescent devices.

An efficient synthesis of 2-arylimidazoles by oxidation of 2-arylimidazolines using activated carbon-O2 system and its application to palladium-catalyzed Mizoroki-Heck reaction

Oxidative conversion of 2-substituted imidazoline (dihydroimidazole) to the corresponding imidazole was achieved by an activated carbon-O2 system. Also, the 2-arylimidazolines and 2-arylimidazoles have been found to work as simple ligands in the palladium-catalyzed Mizoroki-Heck reaction.