76875-87-1

Basic information

• Product Name: 2-piperidinoethyl N-(4-nitrophenyl)carbamate
• CAS NO: 76875-87-1
• Molecular Weight: 293.323
• Mol File: 76875-87-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-piperidinoethyl N-(4-nitrophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-piperidinoethyl N-(4-nitrophenyl)carbamate(76875-87-1)
• EPA Substance Registry System: 2-piperidinoethyl N-(4-nitrophenyl)carbamate(76875-87-1)

Safety Data

• Hazardous Substances Data: 76875-87-1(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 51028-38-7 (4-nitro-phenyl)-carbamoyl chloride 
• 2733-41-7 4-nitrobenzoyl azide 

Relevant articles and documents

Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors

A series of carbamate derivatives (7) of 2-(1-piperidinyl)ethyl 4- amino-5-chloro-2-methoxybenzoates, which have been described as potent agonists and antagonists of 5-HT4 receptors, were synthesized. They were evaluated using radioligand binding assays with [3H]GR 113808, a 5-HT4 receptor selective ligand, in the rat striatum and the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig. In contrast to the previously described ester derivatives, a drop in the affinity for 5-HT4 receptors was observed and the compounds were inactive as agonists in the guinea pig ileum preparation. Unexpectedly, the ortho- substituted carbamates 8b,c (R' = H, RO = MeO or EtO, R'' = H) had nanomolar affinity for 5-HT4 receptors (K(i) = 8.9 ± 0.5 and 2.6 ± 0.4 nM, respectively). As reported previously, the cis- or trans-3,5-dimethyl substitution of piperidine (8n,o) was particularly favorable (K(i) = 1.1 ± 0.6 nM for both isomers). 8c is an antagonist equipotent to the 5-HT4 receptor antagonist SDZ 205-557 (1).