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1-(carbamoylamino)-2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid, also known as carbamporphyrin, is a dihydropyridine derivative with the molecular formula C10H13N3O4. It is structurally related to the calcium channel blocker nifedipine and is a potent and selective inhibitor of insulin-regulated aminopeptidase (IRAP), an enzyme involved in the metabolism of neuropeptides and regulation of glucose homeostasis.

76877-03-7

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76877-03-7 Usage

Uses

Used in Pharmaceutical Industry:
1-(carbamoylamino)-2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is used as a therapeutic agent for the treatment of neurodegenerative diseases, metabolic disorders, and other conditions related to IRAP activity. Its potent and selective inhibition of IRAP makes it a promising candidate for developing treatments targeting these conditions.
Used in Research Applications:
Carbamporphyrin is also used in research settings to study the role of IRAP in various biological processes. By inhibiting IRAP, researchers can gain insights into the enzyme's function and its potential as a therapeutic target for different diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 76877-03-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,8,7 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 76877-03:
(7*7)+(6*6)+(5*8)+(4*7)+(3*7)+(2*0)+(1*3)=177
177 % 10 = 7
So 76877-03-7 is a valid CAS Registry Number.

76877-03-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(carbamoylamino)-2,4-dimethyl-6-oxopyridine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:76877-03-7 SDS

76877-03-7Downstream Products

76877-03-7Relevant academic research and scientific papers

Synthesis of 1-Substituted-5-carboxy-4,6-dimethyl-2(1H)pyridones

Singh, C. P.

, p. 980 (2007/10/02)

A number of 1-substituted-5-carboxy-4,6-dimethyl-2(1H)-pyridones have been synthesised by the condensation of 4,6-dimethyl-5-carboxy-2-oxo-(2H)-pyran with substituted-hydrazines.Their structural assignments are based on elemental analyses, ir ands nmr spectral data.

Synthesis of α-Pyridones by Condensation of Isodehydroacetic Acid with Substituted Hydrazines

Ojha, A. C.,Rastogi, S. N.,Manohar, Ram

, p. 720 - 721 (2007/10/02)

1-Substituted 5-carboxy-4,6-dimethyl-2(1H)-pyridones (Ia-j) have been prepared by the reaction of isodehydroacetic acid with hydrazine and substituted hydrazines.Their structural assignments are based on elemental analyses and IR and PMR spectral data.

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