480-65-9

Usage

Chemical Properties

WHITE CRYSTALLINE POWDER

InChI:InChI=1/C8H8O4/c1-4-3-6(9)12-5(2)7(4)8(10)11/h3H,1-2H3,(H,10,11)/p-1

Upstream product

• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 3385-34-0 ethyl isodehydroacetate 
• 7664-93-9 sulfuric acid 
• 41264-06-6 methyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 

Downstream Products

• 675-09-2 4,6-Dimethyl-2-pyron 
• 41264-06-6 methyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate 
• 76877-03-7 2,4-Dimethyl-6-oxo-1-ureido-1,6-dihydro-pyridine-3-carboxylic acid 
• 76876-97-6 1-(4-chlorophenylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76876-95-4 1-(4-nitrophenylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76876-96-5 1-(2,4-dinitrophenylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76877-00-4 1-(2-naphthylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76877-02-6 1-(4-methoxyphenylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76876-98-7 1-(2-chlorophenylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 76876-99-8 1-(1-naphthylamino)-5-carboxy-4,6-dimethyl-2(1H)-pyridone 
• 372-42-9 3-methylpent-2-enedioic acid 
• 76877-04-8 1-Amino-2,4-dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 124-38-9 carbon dioxide 

Relevant academic research and scientific papers

COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS

The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups;of a monocarboxylic acid containing 6 to 32 carbon atoms;of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and(b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

Substrate Diversity of Macrophomate Synthase Catalyzing an Unusual Multistep Transformation from 2-Pyrones to Benzoates

Macrophomale synthase, which we have recently purified, catalyzes an unusual multistep transformation from 5-acetyl-4-methoxy-6-methyl-2-pyrone to 4-acetyl-3-methoxy-5-methyl-benzoic acid (macrophomic acid). To investigate the substrate diversity of the enzyme, 40 analogs of 2-pyrone were prepared and their relative efficiency was examined in the enzymatic conversions. The experimental results reveal the structural requirements of the substrates and the rough size of the enzyme active site, and eliminate the ambiguity caused by contamination by other enzymes in the whole-cell experiments.

An improved synthesis of a mixture of diethyl (Z)- and (E)-3-methylglutaconates from ethyl acetoacetate

A simple, efficient two-step synthesis of a mixture of diethyl (Z)- and (E)-3-methylglutaconates from isodehydroacetic acid in 83% yield is described. On the basis of this synthesis an improved procedure for the preparation of a mixture of (Z)- and (E)-3-methylglutaconic acids from ethyl acetoacetate in 44% overall yield was elaborated.

Studies on Metabolites of Macrophoma commelinae. IV. Substrate Specificity in the Biotransformation of 2-Pyrones to Substituted Benzoic Acids

Substrate specificity in the novel biotransformation from 2-pyrone derivatives to substituted benzoic acids by Macrophoma commelinae (IFO 9570) was investigated by means of feeding experiments with various compounds.Among them, 2-pyrone derivatives substituted by an electron-donating group at C-4, by an electron-withdrawing group at C-5 and by an alkyl group at C-6 were converted to the corresponding benzoic acid derivatives in fairly good yields.The C3-unit precursors and intermediates were examined in stationary or shaking culture.Based on the experimental results obtained, a mechanism for this unique reaction is proposed. macrophoma commelinae IFO 9570; fungi; 2-pyrone; substituted benzoic acid; biotransformation; substrate specificity; aromatic ring formation; macrophomic acid