76885-47-7Relevant academic research and scientific papers
A NEW METHOD FOR THE GENERATION OF ISOBENZOFURANS: A SIMPLE ENTRY TO SUBSTITUTED NAPHTHALENES.
Keay, B. A.,Lee, D. K. W.,Rodrigo, R.
, p. 3663 - 3666 (1980)
5,6-Dimethoxy isobenzofuran is generated in situ from the dimethylacetal of 6-hydroxymethyl veratraldehyde and intercepted by a variety of dienophiles to produce the expected oxygen-bridged adducts in good yield.Many of the latter are easily aromatised to
Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3- bis(hydroxymethyl)naphthalene lignans
Iwasaki, Tameo,Kondo, Kazuhiko,Kuroda, Tooru,Moritani, Yasunori,Yamagata, Shinsuke,Sugiura, Masaki,Kikkawa, Hideo,Kaminuma, Osamu,Ikezawa, Katsuo
, p. 2696 - 2704 (2007/10/03)
A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of the
Hydroxyacetals, phtalans, and isobenzofurans therefrom
Keay, Brian A.,Plaumann, Heinz P.,Rajapaksa, Dayananda,Rodrigo, Russell
, p. 1987 - 1995 (2007/10/02)
A general method for the generation of isobenzofuran intermediates is described.Lithiated aromatic acetals are converted to hydroxyacetals (A) which may be cyclized to isobenzofurans by mild acid treatment through the 1-hydroxyphtalans (B).The isobenzofur
