76892-42-7Relevant academic research and scientific papers
Discovery of phthalimides as immunomodulatory and antitumor drug prototypes
Pessoa, Claudia,Ferreira, Paulo Michel P.,Lotufo, Leticia Veras C.,DeMoraes, Manoel O.,Cavalcanti, Suellen M. T.,Coelho, Lucas Cunha D.,Hernandes, Marcelo Z.,Leite, Ana Cristina L.,DeSimone, Carlos A.,Costa, Vlaudia M. A.,Souza, Valdenia M. O.
scheme or table, p. 523 - 528 (2010/12/25)
Optimized anticancer agents: A set of functionalized phthalimides was synthesized and evaluated for antitumor activities and as modulators of the secretion of cytokines and nitric oxide. Their potency was compared with that of thalidomide, and as a result, a new potent anticancer and immunomodulatory agent, compound 2b, was identified.
The Reaction of N-Aminophthalimide With Isothiocyanates
Hearn, Michael J.,Lucas, Laura E.
, p. 615 - 616 (2007/10/02)
N-Aminophthalimide (I) reacted in refluxing isopropyl alcohol with a number of isothiocyanates to give the related 1:1 addition products, N-(3-substituted thioureido)phthalimides III.On the other hand, heating I directly with an excess of neat arylisothiocyanates produced the N-arylphthalimides IV.As shown for IIIa, the 1:1 addition products are conveniently deblocked by the Ing-Manske procedure to yield the 4-substituted thiosemicarbazide.
Phthalimidoguanidine plant growth regulators
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, (2008/06/13)
Novel compounds are disclosed which have utility as plant growth regulators. Use to produce growth regulators is specifically illustrated. The novel compounds of this invention are phthalimidoguanidines of the following general structural formulas: STR1 in which R, R1 and R5 are hydrogen, C1 to C5 alkyl, R2 and R3 are alike or unlike, one of which may be hydrogen but otherwise are substituents selected from C1 to C5 alkyl, alkenyl or alkynyl, branched or unbranched, C2 to C5 hydroxyalkyl or alkoxyalkyl, C3 to C5 cycloalkyl, furfuryl, pyridyl, benzyl, phenyl, C1 to C5 alkylphenyl, or --NR2 R3 together may be 2,5-dimethyl-1-pyrryl, 4-morpholinyl or 1-pyrrolidinyl, R4 is halogen, nitro, cyano, trifluoromethyl, C1 to C5 alkyl or acyl and n is zero, one or two.
N-(arylthiocarbamoyl)-2-amino-1H-isoindole-1,3-(2H)diones and use as plant growth regulators
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, (2008/06/13)
A novel class of compounds which are useful as plant growth regulators is disclosed, having the general structural formula: STR1 in which R1 is; C1 to C4 alkyl, nitro or halo and n is zero or an integer from 1 to 4 R2 and R3 are; H or C1 to C4 alkyl or hydroxyalkyl, or benzyl and Ar is; adamantyl, C3 to C4 alkyl or alkenyl, benzyl, halobenzyl, naphthyl, phenyl or phenyl bearing thereon from one to three of the substituents: cyano, benzyloxy, methylenedioxy, nitro, bromo, chloro, trifluoromethyl and C1 to C4 alkyl, alkenyl, alkoxy, alkylthio and alkyl-substituted amino.
