76892-42-7Relevant articles and documents
Discovery of phthalimides as immunomodulatory and antitumor drug prototypes
Pessoa, Claudia,Ferreira, Paulo Michel P.,Lotufo, Leticia Veras C.,DeMoraes, Manoel O.,Cavalcanti, Suellen M. T.,Coelho, Lucas Cunha D.,Hernandes, Marcelo Z.,Leite, Ana Cristina L.,DeSimone, Carlos A.,Costa, Vlaudia M. A.,Souza, Valdenia M. O.
scheme or table, p. 523 - 528 (2010/12/25)
Optimized anticancer agents: A set of functionalized phthalimides was synthesized and evaluated for antitumor activities and as modulators of the secretion of cytokines and nitric oxide. Their potency was compared with that of thalidomide, and as a result, a new potent anticancer and immunomodulatory agent, compound 2b, was identified.
Phthalimidoguanidine plant growth regulators
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, (2008/06/13)
Novel compounds are disclosed which have utility as plant growth regulators. Use to produce growth regulators is specifically illustrated. The novel compounds of this invention are phthalimidoguanidines of the following general structural formulas: STR1 in which R, R1 and R5 are hydrogen, C1 to C5 alkyl, R2 and R3 are alike or unlike, one of which may be hydrogen but otherwise are substituents selected from C1 to C5 alkyl, alkenyl or alkynyl, branched or unbranched, C2 to C5 hydroxyalkyl or alkoxyalkyl, C3 to C5 cycloalkyl, furfuryl, pyridyl, benzyl, phenyl, C1 to C5 alkylphenyl, or --NR2 R3 together may be 2,5-dimethyl-1-pyrryl, 4-morpholinyl or 1-pyrrolidinyl, R4 is halogen, nitro, cyano, trifluoromethyl, C1 to C5 alkyl or acyl and n is zero, one or two.
