76893-27-1

Usage

InChI:InChI=1/C10H19NO4S/c1-9(2)6-8(7-15-16(5,13)14)10(3,4)11(9)12/h6,12H,7H2,1-5H3

Upstream product

• 2154-32-7 methyl 1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-carboxylate radical 
• 19971-12-1 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidine Hydrobromide 
• 70473-81-3 2,2,5,5-tetramethyl-2,5-dihydropyrrole-3-carboxylic acid methyl ester 
• 57167-75-6 3,5-dibromo-2,2,6,6-tetramethylpiperidin-4-one 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 55738-75-5 (2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 76893-32-8 3-(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-oxyl 
• 76893-33-9 3-Iodomethyl-2,2,5,5-tetramethyl-2,5-dihydropyrrole-1-oxyl 
• 76893-37-3 C₂₀H₂₉N₂O₄*C₂H₄O₂ 
• 76893-38-4 2,5-dihydro-2,2,5,5-tetramethyl-3-phenylthiomethyl-1H-pyrrol-1-yloxy radical 
• 83040-07-7 1-oxyl-2,2,5,5-tetramethyl-3-(4-acetylphenoxymethyl)pyrroline 
• 206354-38-3 6-chloro-2-[(1-oxyl-2,2,5,5-tetramethyl-pyrrolin-3-yl)methyloxy]-9-phenoxy-acridine 
• 76893-43-1 3-Phenylsulfonylmethyl-2,2,5,5-tetramethyl-2,5-dihydropyrrole-1-oxyl 
• 76893-42-0 3-(2,4-Dinitrophenylthiomethyl)-2,2,5,5-tetramethyl-2,5-dihydropyrrole-1-oxyl 
• 78140-45-1 C₂₇H₃₀N₂OP 
• 78140-49-5 3-<(N-methyl-N-triphenylphosphoranylideneammonio)-methyl>-2,2,5,5-tetramethyl-2,5-dihydropyrrole-1-oxyl iodide 
• 82954-79-8 ethyl 2-benzyloxycarbonylamino-3-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolin-3-yl)propionate 
• 83040-08-8 1-oxyl-2,2,5,5-tetramethyl-3-(4-bromoacetylphenoxymethyl)pyrroline 
• 76893-31-7 1-Oxyl-2,2,5,5-tetramethyl-2,5-dihydropyrrole-3-ylmethyl benzoate 

Relevant academic research and scientific papers

Synthesis of Chiral Spin-Labeled Amino Acids

Spin-labeled amino acids (SLAAs) are often used to determine intermolecular distances and conformations in proteins via double electron-electron resonance. Currently available SLAAs can be difficult to incorporate selectively and have little resemblance to natural side chains in proteins. Enantioselective synthesis of three spin-labeled l-amino acids is described, starting from readily available 2,2,6,6-tetramethyl-4-piperidinone. These SLAAs better replicate canonical residues in proteins and aim for biological incorporation via genetic incorporation or solid-phase peptide synthesis.

2′-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2′-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of spin labels enable the use of double electron-electron resonance experiments to measure a number of distances on the duplex, affording a high level of detailed structural information.

An efficient synthesis of 3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy

Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed.

STEROIDAL ANTI-HORMONE HYBRIDS

Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.