76896-61-2

Upstream product

• 4318-56-3 3-methyl-6-chlorouracil 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 76896-38-3 C₂₉H₂₄F₂N₆O₄ 
• 1079130-07-6 C₃₉H₅₀FN₃O₂ 
• 76896-50-9 10-(4-Fluoro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 112069-65-5 10-(4-Fluoro-phenyl)-3-methyl-10H-benzo[g]pteridine-2,4-dione 

Relevant academic research and scientific papers

Flavins as Potential Antimalarials. 1. 10-(Halophenyl)-3-methylflavins

A series of 10-(halomethyl)-3-methylflavins was prepared by the condensation of 6-(haloanilino)-3-methyluracils with nitrosobenzene.A number of these flavins effectively cured lethal Plasmodium vinckei malarial infections in mice when administered by eith

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

Synthesis of 10-Arylpyrimidoquinoline-2,4(3H,10H)diones (10-Aryl-5-deazaflavins) and Their Use in Oxidations of Alcohols and Amines

Treatment of aryl-bis(6-anilino-3-methyluracil-5-yl)methanes, which were prepared by the condensation of 6-anilino-3-methyluracils with arylaldehydes, with diethyl azodicarboxylate (DAD) in the presence of sulfolane led to the formation of the corresponding 10-arylpyrimidoquinoline-2,4(3H,10H)-diones (10-aryl-5-deazaflavins).Heating of the methanes alone in sulfolane without DAD gave the corresponding 5-aryl-5-deazaalloxazines.The oxidizing abilities of the 10-aryl-5-deazaflavins thus obtained were examined from both kinetic and synthetic viewpoints.The oxidations of benzyl alcohol and benzylamine by these 5-deazaflavins have been shown to recycle automatically, and more than 100percent yield of benzaldehyde (based on the 5-deazaflavins) was obtained.Keywords - pyrimidoquinoline; 5-deazaflavin; alcohol oxidation; amine oxidation; diethyl azodicarboxylate; aryl-bis(6-anilinouracil-5-yl)methane; 5-deazaalloxazine; turn-over catalyst; biomimetic axidation.